Evidence map›Paper›PMID 30306467›Full record

SynthesisSports medicine (Auckland, N.Z.)2019

Effects of Blood Flow Restriction Training on Muscular Strength and Hypertrophy in Older Individuals: A Systematic Review and Meta-Analysis.

Christoph Centner, Patrick Wiegel, Albert Gollhofer, Daniel König

Erratum issued 6 registry-linked trialsOpen access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Sports medicine (Auckland, N.Z.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 6 registered trials, which are not on this map. Cited by 178 papers, 26 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
178citing papers in PubMed, 26 pooled it
28.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04222231 naunknown statusnot on this map

Metabolic Effects of a New Resistance Training in Individuals With Type 2 Diabetes

TypeinterventionalSponsorGerman Diabetes CenterRan2019 to 2024Enrolled24ConditionsType 2 DiabetesArmsBlood-flow restriction resistance training, Classical resistance training
NCT04448236 nacompletednot on this mapstarted 2020, after this paper: background citation

Effects on Muscle Strength After Blood Flow Restriction Resistance Exercise (BFR-RE) in Early In-patient Rehabilitation of Chronic Obstructive Pulmonary Disease Acute Exacerbation (COPDAE), a Single Blinded, Randomized Controlled Study

TypeinterventionalSponsorHospital Authority, Hong KongRan2020 to 2020Enrolled53ConditionsChronic Obstructive Pulmonary Disease, Acute Exacerbation of COPDArmsBlood flow restriction resistance exercise
NCT04809714 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

The Role of Blood Flow Restriction Therapy in the Postop Rehabilitation of Elderly Patients With Hip Fractures: A Randomized Controlled Pilot Study

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2022 to 2027Enrolled20ConditionsHip Fractures, Muscle AtrophyArmsBlood Flow Restriction with Delfi Tourniquet System Cuff, Routine Post-operative Physical Therapy
NCT05437770 nacompletednot on this mapstarted 2022, after this paper: background citation

Effects of Low-intensity Blood-flow Restricted Exercise Compared to Standard Rehabilitation in Patients With Knee Osteoarthritis - a Randomized Controlled Trial

TypeinterventionalSponsorBispebjerg HospitalRan2022 to 2025Enrolled96ConditionsOsteoarthritis, KneeArmsBFR (Blood-Flow Restricted exercise), Standard rehabilitation
NCT07722975 nacompletednot on this mapstarted 2026, after this paper: background citation

Effects of Intermittent Versus Continuous Blood Flow Restriction Training on Pain, Functional Ability, Muscle Strength and Exercise Perception Among Female Patients With Grade II Knee Osteoarthritis

TypeinterventionalSponsorLahore University of Biological and Applied SciencesRan2026 to 2026Enrolled84ConditionsKnee OsteoarthristisArmsIntermittent blood flow training (iBFR), Continuous blood flow training (cBFR)
NCT07723014 narecruitingnot on this mapstarted 2026, after this paper: background citation

Effects of Stecco Fascial Manipulation Versus Muscle Energy Technique on Pain Pressure Threshold, Range of Motion and Disability Among Patients With Sacroiliac Joint Dysfunction

TypeinterventionalSponsorLahore University of Biological and Applied SciencesRan2026 to 2026Enrolled52ConditionsSacroiliac Joint DysfunctionArmsStecco fascial manipulation, Muscle energy technique
3 · Its place in the literature

Who cites it

178 citing papers in PubMed, 26 syntheses or guidelines pooled it, 338 citations in OpenAlex.

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  8. Effect of Blood Flow Restriction on Gait and Mobility in Older Adults: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2024
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118 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Christoph CentnerDepartment of Sport and Sport Science, University of Freiburg, Freiburg, Germany. christoph.centner@sport.uni-freiburg.de.ORCID http://orcid.org/0000-0001-6839-4438
Patrick WiegelDepartment of Sport and Sport Science, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0001-5034-7174
Albert GollhoferDepartment of Sport and Sport Science, University of Freiburg, Freiburg, Germany.
Daniel KönigDepartment of Sport and Sport Science, University of Freiburg, Freiburg, Germany.
University of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe combination of low-load resistance training with blood flow restriction (BFR) has recently been shown to promote muscular adaptations in various populations. To date, however, evidence is sparse on how this training regimen influences muscle mass and strength in older adults. PURPOSE: The purpose of this systematic review and meta-analysis was to quantitatively identify the effects of low-load BFR (LL-BFR) training on muscle mass and strength in older individuals in comparison with conventional resistance training programmes. Additionally, the effectiveness of walking with and without BFR was assessed.

methodsA PRISMA-compliant systematic review and meta-analysis was conducted. The systematic literature research was performed in the following electronic databases from inception to 1 June 2018: PubMed, Web of Science, Scopus, CINAHL, SPORTDiscus and CENTRAL. Subsequently, a random-effects meta-analysis with inverse variance weighting was conducted.

resultsA total of 2658 articles were screened, and 11 studies with a total population of N = 238 were included in the meta-analysis. Our results revealed that during both low-load training and walking, the addition of BFR elicits significantly greater improvements in muscular strength with pooled effect sizes (ES) of 2.16 (95% CI 1.61 to 2.70) and 3.09 (95% CI 2.04 to 4.14), respectively. Muscle mass was also increased when comparing walking with and without BFR [ES 1.82 (95% CI 1.32 to 2.32)]. In comparison with high-load training, LL-BFR promotes similar muscle hypertrophy [ES 0.21 (95% CI - 0.14 to 0.56)] but lower strength gains [ES - 0.42 (95% CI - 0.70 to - 0.14)].

conclusionThis systematic review and meta-analysis reveals that LL-BFR and walking with BFR is an effective interventional approach to stimulate muscle hypertrophy and strength gains in older populations. As BFR literature is still scarce with regard to potential moderator variables (e.g. sex, cuff pressure or training volume/frequency), further research is needed for strengthening the evidence for an effective application of LL-BFR training in older people.

Indexed as

Muscle StrengthRegional Blood FlowAgedConstrictionHumansMuscle, SkeletalResistance TrainingWalking

Identifiers

PMID30306467
PMCPMC6349784
OpenAlexW2895829325

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.