Evidence map›Paper›PMID 30306423›Full record

ArticleEuropean journal of epidemiology2019

Copenhagen Baby Heart Study: a population study of newborns with prenatal inclusion.

Anne-Sophie Sillesen, Anna Axelsson Raja, Christian Pihl, Ruth Ottilia Birgitta Vøgg, Morten Hedegaard, Pernille Emmersen, Karin Sundberg, Ann Tabor, Cathrine Vedel, Helle Zingenberg and 13 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 54 citations in OpenAlex.

  1. The Wolff-Parkinson-White pattern in neonates: results from a large population-based cohort study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Trial
  2. Risk of minor congenital heart defect in infants conceived via assisted reproductive technology: cohort study from the Copenhagen Baby Heart Study.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 2 institutions in 1 country.

Anne-Sophie SillesenDepartment of Cardiology, The Heart Centre, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, Copenhagen, 2100, Denmark. anne-sophie.sillesen@regionh.dk.ORCID http://orcid.org/0000-0001-7993-1016
Anna Axelsson RajaDepartment of Cardiology, Copenhagen University Hospital Herlev, Copenhagen, Denmark.
Christian PihlDepartment of Cardiology, Copenhagen University Hospital Herlev, Copenhagen, Denmark.
Ruth Ottilia Birgitta VøggDepartment of Cardiology, Copenhagen University Hospital Herlev, Copenhagen, Denmark.
Morten HedegaardFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Pernille EmmersenFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Karin SundbergFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ann TaborFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Cathrine VedelFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Helle ZingenbergFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Charlotte KruseFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Charlotte Wilken-JensenFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Tina Holm NielsenFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Finn Stener JørgensenFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Dorthe Lisbeth JeppesenFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Lars SøndergaardDepartment of Cardiology, The Heart Centre, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, Copenhagen, 2100, Denmark.
Pia R KamstrupFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Børge G NordestgaardFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ruth Frikke-SchmidtFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Niels VejlstrupDepartment of Cardiology, The Heart Centre, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, Copenhagen, 2100, Denmark.
Heather A BoydDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Henning BundgaardDepartment of Cardiology, The Heart Centre, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, Copenhagen, 2100, Denmark.
Kasper IversenDepartment of Cardiology, Copenhagen University Hospital Herlev, Copenhagen, Denmark.
University of Copenhagen · DKStatens Serum Institut · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital heart diseases (CHDs) are reported in 0.8% of newborns. Numerous factors influence cardiovascular development and CHD prevalence, and possibly also development of cardiovascular disease later in life. However, known factors explain the probable etiology in only a fraction of patients. Past large-scale population-based studies have made invaluable contributions to the understanding of cardiac disease, but none recruited participants prenatally and focused on the neonatal period. The Copenhagen Baby Heart Study (CBHS) is a population-based study of the prevalence, spectrum, and prognosis of structural and functional cardiac abnormalities. The CBHS will also establish normal values for neonatal cardiac parameters and biomarkers, and study prenatal and early childhood factors potentially affecting later cardiovascular disease risk. The CBHS is an ongoing multicenter, prospective study recruiting from second trimester pregnancy (gestational weeks 18-20) (expected n = 25,000). Information on parents, pregnancy, and delivery are collected. After birth, umbilical cord blood is collected for biochemical analysis, DNA purification, and biobank storage. An echocardiographic examination, electrocardiography, and post-ductal pulse oximetry are performed shortly after birth. Infants diagnosed with significant CHD are referred to a specialist or admitted to hospital, depending on CHD severity. CBHS participants will be followed prospectively as part of specific research projects or regular clinical follow-up for CHD. CBHS design and methodology are described. The CBHS aims to identify new mechanisms underlying cardiovascular disease development and new targets for prevention, early detection, and management of CHD and other cardiac diseases presenting at birth or developing later in life.

Indexed as

DenmarkDNAEchocardiographyElectrocardiographyFemaleHeart Defects, CongenitalHumansInfant, NewbornMalePregnancyPregnancy Trimester, SecondPrognosisProspective StudiesReference ValuesResearch DesignRisk FactorsDNACardiovascular developmentCardiovascular diseaseCongenital heart diseaseEpidemiologyReference materialRisk factors

Identifiers

PMID30306423
OpenAlexW2898005647

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.