ReviewCurrent psychiatry reports2018
Gender-Affirming Hormone Use in Transgender Individuals: Impact on Behavioral Health and Cognition.
Review in Current psychiatry reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 2 syntheses or guidelines pooled it, 179 citations in OpenAlex.
- A systematic review of psychosocial functioning changes after gender-affirming hormone therapy among transgender people.Nature human behaviour · 2023Pooled it
- The Prevalence of Frascati-Criteria-Based HIV-Associated Neurocognitive Disorder (HAND) in HIV-Infected Adults: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2020Pooled it
- Gender reassignment and neurosurgical implications: a narrative review.Chinese neurosurgical journal · 2026Review
- Diet quality and nutritional health among transgender and gender-diverse youth and young adults: mixed methods results from Project Gender NutriScope.BMC nutrition · 2026Article
- Gender Identity Milestones and Hormone Utilization in Transgender Men and Women in China.JAMA network open · 2026Article
- Explicit gender stereotypes and sexually polymorphic cognition by gender identity.Biology of sex differences · 2025Article
- Gender Identity and Mental Health Symptom Severity Among Adolescents Admitted to an Inpatient Psychiatric Hospital.Child psychiatry and human development · 2025Article
- Modulation of Auditory Cortex Activity in Salicylate-Induced Tinnitus Rats via Deep Brain Stimulation of the Inferior Colliculus.Brain and behavior · 2025Article
- Medical gender affirmation appears protective against problematic substance use among transgender women and transfeminine adults: Findings from The LITE Study.Drug and alcohol dependence · 2025Article
- Article
- Gender-affirming hormone therapy, quality of life, and the role of oestradiol and testosterone in transgender individuals.Acta neuropsychiatrica · 2025Article
- Leveraging the Electronic Health Record to Characterize Health Care Utilization and Stressors Before a Suicide Attempt Among Transgender and Gender Diverse Patients.Transgender health · 2025Article
- Leveraging research into sex differences and steroid hormones to improve brain health.Nature reviews. Endocrinology · 2025Review
- Hormones, Stress, and Heart Disease in Transgender Women with HIV in LITE Plus.American journal of preventive medicine · 2025Observational
- Gender-affirming care education in pharmacy: a scoping review protocol of practices in Canada and the USA.BMJ open · 2025Article
- Systematic review of prospective adult mental health outcomes following affirmative interventions for gender dysphoria.International journal of transgender health · 2025Review
- Cognitive functioning in older transgender individuals receiving long-term gender-affirming hormone therapy.International journal of transgender health · 2025Article
- Adaptive transition decisions and identity exploration among transgender and nonbinary persons exposed to gender identity conversion efforts.International journal of transgender health · 2025Article
- High Rates of High-risk HPV Anal Infection and Abnormal Cytology in a Cohort of Transgender People Assigned Male at Birth.Open forum infectious diseases · 2024Article
- Primary care provider beliefs and knowledge of prescribing gender-affirming hormone therapy to transgender and gender diverse patients.BMC primary care · 2024Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewWith increasing numbers of transgender and gender non-binary individuals presenting for care, knowing how to elucidate the mental health and cognitive outcomes of gender-affirming hormone therapy (GAHT) is necessary. This article reviews the present literature covering GAHT effects on mood, behavioral health, and cognition in these individuals and offers research priorities to address knowledge gaps. RECENT
findingsAlthough there are some conflicting data, GAHT overwhelmingly seems to have positive psychological effects in both adolescents and adults. Research tends to support that GAHT reduces symptoms of anxiety and depression, lowers perceived and social distress, and improves quality of life and self-esteem in both male-to-female and female-to-male transgender individuals. Clinically, prescribing GAHT can help with gender dysphoria-related mental distress. Thus, timely hormonal intervention represents a crucial tool for improving behavioral wellness in transgender individuals, though effects on cognitive processes fundamental for daily living are unknown. Future research should prioritize better understanding of how GAHT may affect executive functioning.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.