Evidence map›Paper›PMID 30306318›Full record

ArticleMolecular imaging and biology2019

Evaluation of the Novel PET Tracer [

Jasper van der Aart, Maqsood Yaqub, Esther J M Kooijman, Jaco Bakker, Jan A M Langermans, Robert C Schuit, Mark B M Hofman, Johannes A M Christiaans, Adriaan A Lammertsma, Albert D Windhorst and 1 more

Open access · hybridAbstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. A Review of Molecular Imaging of Glutamate Receptors.Molecules (Basel, Switzerland) · 2020
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jasper van der AartDepartment of Radiology & Nuclear Medicine, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands. jaspervanderaart@gmail.com.
Maqsood YaqubDepartment of Radiology & Nuclear Medicine, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands.
Esther J M KooijmanDepartment of Radiology & Nuclear Medicine, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands.
Jaco BakkerAnimal Science Department, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
Jan A M LangermansAnimal Science Department, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
Robert C SchuitDepartment of Radiology & Nuclear Medicine, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands.
Mark B M HofmanDepartment of Radiology & Nuclear Medicine, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands.
Johannes A M ChristiaansDepartment of Radiology & Nuclear Medicine, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands.
Adriaan A LammertsmaDepartment of Radiology & Nuclear Medicine, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands.
Albert D WindhorstDepartment of Radiology & Nuclear Medicine, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands.
Bart N M van BerckelDepartment of Radiology & Nuclear Medicine, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands.
Amsterdam UMC Location VUmc · NLBiomedical Primate Research Centre · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThere are currently no positron emission tomography (PET) radiotracers for the GluN2B (NR2B) binding sites of brain N-methyl-D-aspartate (NMDA) receptors. In rats, the GluN2B antagonist Ro25-6981 reduced the binding of N-((5-(4-fluoro-2-[ PROCEDURES: Eight 90-min dynamic [

results[

conclusionsThe present results show that [

Indexed as

Molecular ImagingPositron-Emission TomographyAcetamidesAnimalsArea Under CurveBrainCarbon RadioisotopesMacaca mulattaMalePiperidinesRadiopharmaceuticalsReceptors, N-Methyl-D-AspartateAcetamidesCarbon-11Carbon RadioisotopesNR2B NMDA receptorPiperidinesRadiopharmaceuticalsradiprodilReceptors, N-Methyl-D-Aspartate[11C]HACH242GluN2BNMDANR2BPETRadiprodil

Identifiers

PMID30306318
OpenAlexW2896030299

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.