Evidence map›Paper›PMID 30306273›Full record

ArticlePharmaceutical research2018

Sustained Release from Ionic-Gradient Liposomes Significantly Decreases ETIDOCAINE Cytotoxicity.

Juliana Damasceno Oliveira, Lígia Nunes de Morais Ribeiro, Gustavo Henrique Rodrigues da Silva, Bruna Renata Casadei, Verônica Muniz Couto, Elizabeth Ferreira Martinez, Eneida de Paula

Abstract read
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In one paragraph

Article in Pharmaceutical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Juliana Damasceno OliveiraDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas - Unicamp, P.O. Box - 6109, CEP, Campinas, SP, 13083-862, Brazil.
Lígia Nunes de Morais RibeiroDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas - Unicamp, P.O. Box - 6109, CEP, Campinas, SP, 13083-862, Brazil.
Gustavo Henrique Rodrigues da SilvaDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas - Unicamp, P.O. Box - 6109, CEP, Campinas, SP, 13083-862, Brazil.
Bruna Renata CasadeiDepartment of Biophysics, Federal University of São Paulo - UNIFESP, São Paulo, São Paulo, Brazil.
Verônica Muniz CoutoDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas - Unicamp, P.O. Box - 6109, CEP, Campinas, SP, 13083-862, Brazil.
Elizabeth Ferreira MartinezDepartment of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Campinas, São Paulo, Brazil.
Eneida de PaulaDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas - Unicamp, P.O. Box - 6109, CEP, Campinas, SP, 13083-862, Brazil. depaula@unicamp.br.ORCID http://orcid.org/0000-0003-4504-5723
Universidade Estadual de Campinas (UNICAMP) · BRFaculdade São Leopoldo Mandic · BRUniversidade Federal de São Paulo · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2014/14457-5
6 · The paper itself

Abstract

purposeEtidocaine (EDC) is a long lasting local anesthetic, which alleged toxicity has restricted its clinical use. Liposomes can prolong the analgesia time and reduce the toxicity of local anesthetics. Ionic gradient liposomes (IGL) have been proposed to increase the upload and prolong the drug release, from liposomes.

methodsFirst, a HPLC method for EDC quantification was validated. Then, large unilamellar vesicles composed of hydrogenated soy phosphatidylcholine:cholesterol with 250 mM (NH

resultsIGL

conclusionA novel formulation is proposed for etidocaine that promotes sustained release and reduces its cytotoxicity. IGL

Indexed as

Anesthetics, LocalCell LineCell SurvivalCholesterolDelayed-Action PreparationsDrug LiberationEtidocaineFibroblastsHumansIonsLiposomesPhosphatidylcholinesAnesthetics, LocalCholesterolDelayed-Action PreparationsEtidocaineIonsLiposomesPhosphatidylcholinesdrug-deliveryetidocaineionic gradient liposomeslocal anesthesia

Identifiers

PMID30306273
OpenAlexW2896728385

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.