Evidence map›Paper›PMID 30306243›Full record

ArticleExperimental brain research2019

Neuromuscular electrical stimulation increases serum brain-derived neurotrophic factor in humans.

Takehide Kimura, Fuminari Kaneko, Erika Iwamoto, Shigeyuki Saitoh, Takashi Yamada

Abstract read
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In one paragraph

Article in Experimental brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Takehide KimuraGraduate School of Health Sciences, Sapporo Medical University, W17-S1 Chuo-ku, Sapporo, Hokkaido, 060-8556, Japan.
Fuminari KanekoFirst Division of Physical Therapy, School of Health Sciences, Sapporo Medical University, W17-S1 Chuo-ku, Sapporo, Hokkaido, 060-8556, Japan. f-kaneko@keio.jp.
Erika IwamotoSecond Division of Physical Therapy, School of Health Sciences, Sapporo Medical University, W17-S1 Chuo-ku, Sapporo, Hokkaido, 060-8556, Japan.
Shigeyuki SaitohDepartment of Nursing, School of Health Sciences, Sapporo Medical University, W17-S1 Chuo-ku, Sapporo, Hokkaido, 060-8556, Japan.
Takashi YamadaFirst Division of Physical Therapy, School of Health Sciences, Sapporo Medical University, W17-S1 Chuo-ku, Sapporo, Hokkaido, 060-8556, Japan.
Sapporo Medical University · JPTsukuba International University · JP

Funding

Grants-in-Aid for Challenging Exploratory Research 24650322
6 · The paper itself

Abstract

Brain-derived neurotrophic factor (BDNF) plays several important roles in nervous system function including neuronal growth and plasticity. The purpose of the present study was to clarify whether neuromuscular electrical stimulation (NMES) and voluntary exercise to the same integrated force as by the NMES-induced exercise would enhance serum BDNF. Eleven healthy male subjects completed three interventions (NMES, voluntary exercise, and resting interventions) for 20 min on different days. In the NMES intervention, NMES was applied to the quadriceps femoris muscles. The stimulus intensity of NMES was progressively increased to the highest tolerated intensity during the experiment. In the voluntary exercise intervention, subjects performed an isometric knee-extension task; in this intervention, the target torque was calculated in accordance with the integrated force of knee extension obtained during the NMES intervention. In the resting intervention, subjects relaxed in a sitting posture. We measured serum BDNF, blood lactate, heart rate, oxygen uptake, respiratory ratio, and blood pressure. Serum BDNF was increased in the NMES (p = 0.003) and voluntary exercise interventions (p = 0.004) after each intervention. At the post-timepoint, serum BDNF in the NMES intervention was highest among all interventions (p = 0.038) and significantly higher than in the voluntary exercise (p = 0.036) and resting (p = 0.037) interventions. Our results showed that NMES was more effective for enhancing serum BDNF than voluntary exercise at least when employing the same method and integrated force.

Indexed as

Blood PressureBrain-Derived Neurotrophic FactorElectric StimulationElectromyographyExerciseFemaleHeart RateHumansIsometric ContractionKneeLactic AcidMaleOxygen ConsumptionQuadriceps MuscleRespirationYoung AdultBrain-Derived Neurotrophic FactorLactic AcidBlood lactateBrain-derived neurotrophic factorNeuromuscular electrical stimulationVoluntary exercise

Identifiers

PMID30306243
OpenAlexW2896727613

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.