Evidence map›Paper›PMID 30306067›Full record

ArticleJournal of biological research (Thessalonike, Greece)2018

MicroRNA expression profile of urinary exosomes in Type IV lupus nephritis complicated by cellular crescent.

Yi Li, Xiaosong Xu, Xiaopeng Tang, Xiuwu Bian, Bingbing Shen, Hongwen Zhao, Shiyuan Luo, Zhiwen Chen, Keqin Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biological research (Thessalonike, Greece), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 36 citations in OpenAlex.

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  12. The Role of Extracellular Vesicles in Systemic Lupus Erythematosus.Frontiers in cell and developmental biology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yi LiDepartment of Nephrology, The First Hospital Affiliated To Army Medical University, No. 29 Gaotanyan Street, Sha Ping Ba District, Chongqing, 400038 China.
Xiaosong XuDepartment of Nephrology, The First Hospital Affiliated To Army Medical University, No. 29 Gaotanyan Street, Sha Ping Ba District, Chongqing, 400038 China.
Xiaopeng TangDepartment of Nephrology, The First Hospital Affiliated To Army Medical University, No. 29 Gaotanyan Street, Sha Ping Ba District, Chongqing, 400038 China.
Xiuwu BianDepartment of Pathology, The First Hospital Affiliated To Army Medical University, No. 29 Gaotanyan Street, Sha Ping Ba District, Chongqing, 400038 China.
Bingbing ShenDepartment of Nephrology, The First Hospital Affiliated To Army Medical University, No. 29 Gaotanyan Street, Sha Ping Ba District, Chongqing, 400038 China.
Hongwen ZhaoDepartment of Nephrology, The First Hospital Affiliated To Army Medical University, No. 29 Gaotanyan Street, Sha Ping Ba District, Chongqing, 400038 China.
Shiyuan LuoDepartment of Nephrology, The First Hospital Affiliated To Army Medical University, No. 29 Gaotanyan Street, Sha Ping Ba District, Chongqing, 400038 China.
Zhiwen ChenDepartment of Urology, The First Hospital Affiliated To Army Medical University, No. 29 Gaotanyan Street, Sha Ping Ba District, Chongqing, 400038 China.
Keqin ZhangDepartment of Nephrology, The First Hospital Affiliated To Army Medical University, No. 29 Gaotanyan Street, Sha Ping Ba District, Chongqing, 400038 China.
Army Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundType IV lupus nephritis (LNIV) is a severe disease characterized by diffuse proliferative lesions, and its prognosis is worse with cellular crescent (LNIV-CC) involvement. Urinary exosomes have been shown to reflect the degree of kidney injury. This study was aimed to identify non-invasive diagnostic markers for LNIV-CC. We analysed the expression profile of microRNAs (miRNAs) isolated from urinary exosomes in patients with LNIV-CC and LNIV, and healthy individuals using high-throughput sequencing.

resultsA total of 66 differentially expressed miRNAs were identified, which were significantly enriched in 15 signalling pathways. Bioinformatic analysis revealed a co-expression network of miRNAs, predicted transcription factors and target mRNAs. Expression of three miRNAs including miR-3135b, miR-654-5p, and miR-146a-5p were further analysed and validated by reverse transcription-quantitative polymerase chain reaction. ROC analysis suggested these as candidate biomarkers for LNIV-CC.

conclusionsLNIV-CC has a unique miRNA expression profile of urinary exosome and complex regulatory network. miR-3135b, miR-654-5p and miR-146a-5p in urinary exosomes could be used as novel non-invasive diagnostic markers for LNIV-CC.

Indexed as

High-throughput sequencingmiRNAsType IV lupus nephritisUrinary exosome

Identifiers

PMID30306067
PMCPMC6172751
OpenAlexW2895434450

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.