ArticleJournal of intensive care2018
The future of driving pressure: a primary goal for mechanical ventilation?
Article in Journal of intensive care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Effects of intraoperative positive end-expiratory pressure optimization on respiratory mechanics and the inflammatory response: a randomized controlled trial.Journal of clinical monitoring and computing · 2021Trial
- Driving pressure-guided individualized PEEP versus fixed low PEEP in obese patients undergoing bariatric surgery: a randomized clinical trial.Journal of anesthesia · 2026Article
- Donor-size-normalized tidal volume and early peak airway pressure-derived pressure burden after lung transplantation: an exploratory single-center cohort study.Frontiers in medicine · 2026Article
- Navigating Hypoxemic Respiratory Failure in Critically Ill Cardiac Patients.JACC. Advances · 2025Review
- Kidney-lung Crosstalk in Determining the Prognosis of Acute Kidney Injury Phenotypes in Acute Respiratory Distress Syndrome Patients.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2023Article
- Intraoperative Ventilator Management of the Critically Ill Patient.Anesthesiology clinics · 2023Review
- Challenges in ARDS Definition, Management, and Identification of Effective Personalized Therapies.Journal of clinical medicine · 2023Review
- Evidence-Based Mechanical Ventilatory Strategies in ARDS.Journal of clinical medicine · 2022Review
- Interpretation and use of intraoperative protective ventilation parameters: a scoping review.Anaesthesiology intensive therapy · 2022Article
- Respiratory Monitoring at Bedside in COVID-19 Patients.Journal of clinical medicine · 2021Review
- Acute Respiratory Distress Syndrome: Ventilator Management and Rescue Therapies.Critical care clinics · 2021Review
- Impact of Height Estimation on Tidal Volume Calculation for Protective Ventilation-A Prospective Observational Study.Critical care explorations · 2021Article
- A Novel Ventilator Design for COVID-19 and Resource-Limited Settings.Frontiers in medical technology · 2021Article
- Initial emergency department mechanical ventilation strategies for COVID-19 hypoxemic respiratory failure and ARDS.The American journal of emergency medicine · 2020Review
- Management of primary blast lung injury: a comparison of airway pressure release versus low tidal volume ventilation.Intensive care medicine experimental · 2020Article
- Targeting Driving Pressure for the Management of ARDS…Isn't It Just Very Low Tidal Volume Ventilation?Annals of the American Thoracic Society · 2020Article
- Driving pressure is not associated with mortality in mechanically ventilated patients without ARDS.Critical care (London, England) · 2019Article
- Development and Internal Validation of a Novel Prognostic Score to Predict Mortality in Acute Respiratory Distress Syndrome - Driving Pressure, Oxygenation and Nutritional Evaluation - "DRONE Score".Journal of emergencies, trauma, and shockArticle
- Optimizing respiratory care in coronavirus disease-2019: A comprehensive, protocolized, evidence-based, algorithmic approach.International journal of critical illness and injury scienceArticle
- Saved by the PEEP: Resolution of Complete Unilateral Lung Collapse Secondary to Mucus Plugging With Ventilator Technique.Journal of investigative medicine high impact case reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundManagement of patients with acute respiratory distress syndrome (ARDS) remains supportive with lung protective mechanical ventilation. In this article, we discuss the physiological concept of driving pressure, current data, ongoing trials, and future directions needed to clarify the role of driving pressure in patients with ARDS. BODY: Driving pressure is the plateau airway pressure minus PEEP. It can also be expressed as the ratio of tidal volume to respiratory system compliance, indicating the decreased functional size of the lung observed in patients with ARDS (i.e., baby lung). Driving pressure as a strong predictor of mortality in patients with ARDS is supported by a post hoc analysis of previous randomized controlled trials and a subsequent meta-analysis. Importantly, the meta-analysis suggested targeting driving pressure below 13-15 cmH2O. Ongoing clinical trials of driving pressure in patients with ARDS focus mainly on physiological rather than clinical outcome but will provide important insights for the design of future clinical trials.
conclusionCurrently, no definite clinical recommendations on the routine use of driving pressure in patients with ARDS can be made, as the available data are hypothesis-generating. Randomized controlled trials are needed to evaluate the efficacy of a driving pressure-based ventilation strategy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.