Evidence map›Paper›PMID 30305743›Full record

ArticleNature2018

The UK Biobank resource with deep phenotyping and genomic data.

Clare Bycroft, Colin Freeman, Desislava Petkova, Gavin Band, Lloyd T Elliott, Kevin Sharp, Allan Motyer, Damjan Vukcevic, Olivier Delaneau, Jared O'Connell and 9 more

2 registry-linked trialsOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 5,461 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5,461citing papers in PubMed, 10 pooled it
460.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04331535 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Pragmatic Randomized Trial of Polygenic Risk Scoring for Common Diseases in Primary Care

TypeinterventionalSponsorBoston VA Research Institute, Inc.Ran2020 to 2025Enrolled1,076ConditionsCoronary Artery Disease, Atrial Fibrillation, Type 2 Diabetes, Colorectal CancerArmsPolygenic risk score (PRS)
NCT04369807 completednot on this mapstarted 2020, after this paper: background citation

Mapping Organ Health Following COVID-19 Disease Due to SARS-CoV-2 Infection

TypeobservationalSponsorPerspectumRan2020 to 2022Enrolled693ConditionsCOVID-19ArmsOutpatient MRI
3 · Its place in the literature

Who cites it

5,461 citing papers in PubMed, 10 syntheses or guidelines pooled it, 9,399 citations in OpenAlex.

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  4. Urate-lowering effects of losartan: a meta-analysis of randomised controlled trials and target trial emulation.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
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5,401 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 4 countries.

Clare BycroftWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Colin FreemanWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Desislava PetkovaWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Gavin BandWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Lloyd T ElliottDepartment of Statistics, University of Oxford, Oxford, UK.
Kevin SharpDepartment of Statistics, University of Oxford, Oxford, UK.
Allan MotyerMelbourne Integrative Genomics and the Schools of Mathematics and Statistics, and BioSciences, The University of Melbourne, Parkville, Victoria, Australia.
Damjan VukcevicMelbourne Integrative Genomics and the Schools of Mathematics and Statistics, and BioSciences, The University of Melbourne, Parkville, Victoria, Australia.
Olivier DelaneauDepartment of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland.
Jared O'ConnellIllumina Ltd, Chesterford Research Park, Little Chesterford, Essex, UK.
Adrian CortesWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Samantha WelshUK Biobank, Adswood, Stockport, Cheshire, UK.
Alan YoungBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
Mark EffinghamUK Biobank, Adswood, Stockport, Cheshire, UK.
Gil McVeanWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Stephen LeslieMelbourne Integrative Genomics and the Schools of Mathematics and Statistics, and BioSciences, The University of Melbourne, Parkville, Victoria, Australia.
Naomi AllenBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
Peter DonnellyWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Jonathan MarchiniWellcome Centre for Human Genetics, University of Oxford, Oxford, UK. marchini@stats.ox.ac.uk.
University of Oxford · GBCentre for Human Genetics · GBMurdoch Children's Research Institute · AUUK Biobank · GBIllumina (United Kingdom) · GBProcter & Gamble (Belgium) · BEUniversity of Geneva · CHUniversity of Melbourne · AU

Funding

Wellcome TrustWellcome Trust 090532/Z/09/ZWellcome Trust 095552/Z/11/ZWellcome Trust 100308/Z/12/ZWellcome Trust 10956/Z/13ZWellcome Trust 203141/Z/16/Z
6 · The paper itself

Abstract

The UK Biobank project is a prospective cohort study with deep genetic and phenotypic data collected on approximately 500,000 individuals from across the United Kingdom, aged between 40 and 69 at recruitment. The open resource is unique in its size and scope. A rich variety of phenotypic and health-related information is available on each participant, including biological measurements, lifestyle indicators, biomarkers in blood and urine, and imaging of the body and brain. Follow-up information is provided by linking health and medical records. Genome-wide genotype data have been collected on all participants, providing many opportunities for the discovery of new genetic associations and the genetic bases of complex traits. Here we describe the centralized analysis of the genetic data, including genotype quality, properties of population structure and relatedness of the genetic data, and efficient phasing and genotype imputation that increases the number of testable variants to around 96 million. Classical allelic variation at 11 human leukocyte antigen genes was imputed, resulting in the recovery of signals with known associations between human leukocyte antigen alleles and many diseases.

Indexed as

Databases, FactualGenomicsPhenotypeAdultAgedAllelesBiomarkersBody HeightBrainCohort StudiesDatabases, GeneticElectronic Health RecordsFamilyFemaleGenome-Wide Association StudyHaplotypesBiomarkers

Identifiers

PMID30305743
PMCPMC6786975
OpenAlexW2895486342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.