ArticleNature2018
IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity.
Open access · bronzeAbstract read
In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 293 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
293citing papers in PubMed, 1 pooled it
15.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
293 citing papers in PubMed, 1 synthesis or guideline pooled it, 396 citations in OpenAlex.
- MAM kinases: physiological roles, related diseases, and therapeutic perspectives-a systematic review.Cellular & molecular biology letters · 2025Pooled it
- Glutamine-driven metabolic reprogramming promotes CAR-T cell function through mTOR-SREBP2 mediated HMGCS1 upregulation in ovarian cancer.Journal of translational medicine · 2025Trial
- Enhancing ovarian cancer immunotherapy through TAGLN2-modified CAR-T cells.Genes & diseases · 2027Article
- XBP1 signaling from tumor metabolic stress to myeloid driven immunotherapy resistance (Review).International journal of molecular medicine · 2026Review
- Metabolic exhaustion and immune ageing in rheumatoid arthritis.Nature reviews. Rheumatology · 2026Review
- Unconventional role of hydroxymethylglutaryl-CoA synthase 1 in driving pathogenic TScience advances · 2026Article
- Post-translational modifications in metabolic reprogramming: implications for metabolic therapy and immunotherapy in cancer.Signal transduction and targeted therapy · 2026Review
- Review
- Metabolic rewiring of the dendritic cell-T cell axis: tumour-derived barriers and therapeutic opportunities.Experimental & molecular medicine · 2026Review
- Translational issues with phototherapy of cancer.Translational oncology · 2026Review
- Targeting colorectal cancer and T‑cell metabolism for the treatment of colorectal cancer (Review).Oncology reports · 2026Review
- Lipids in ovarian cancer ascites impair T cell activation by disrupting TCR dynamics.Nature metabolism · 2026Article
- Redox control at the ER-mitochondria interface in kidney transplantation: MAM-centered stress signaling and translational organoid platforms.Redox biology · 2026Review
- Regulatory Mechanisms of XBP1 in Tumorigenesis and Cancer Progression: Challenges and Therapeutic Strategies.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Targeting TMED4 enhances CD8Science advances · 2026Article
- Single-cell gain-of-function mapping reveals latent regulatory programs governing CD8Research square · 2026Article
- Inhibition of salt-inducible kinases reprograms T cells and antitumor immunity in ovarian cancer.Nature immunology · 2026Article
- T-Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan-Cancer Characteristics, and Therapeutic Interventions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Salt-inducible kinases as druggable targets for immunotherapy of ovarian cancer.Nature immunology · 2026Article
- Fructose 1-phosphate inhibits mannose phosphate isomerase to suppress hepatocellular carcinogenesis.Signal transduction and targeted therapy · 2026Article
233 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors at 9 institutions in 2 countries.
Minkyung SongWeill Cornell Graduate School of Medical Sciences, New York, NY, USA.
Tito A SandovalDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
Chang-Suk ChaeDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
Sahil ChopraWeill Cornell Graduate School of Medical Sciences, New York, NY, USA.
Chen TanDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
Melanie R RutkowskiDepartment of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA, USA.
Mahesh RaundhalDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Ricardo A ChaurioDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Kyle K PayneDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Csaba KonradBrain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Sarah E BettigoleQuentis Therapeutics, Inc, New York, NY, USA.
Hee Rae ShinQuentis Therapeutics, Inc, New York, NY, USA.
Michael J P CrowleyWeill Cornell Graduate School of Medical Sciences, New York, NY, USA.
Juan P CerlianiLaboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
Andrew V KossenkovCenter for Systems and Computational Biology, The Wistar Institute, Philadelphia, PA, USA.
Ievgen MotorykinProteomics & Mass Spectrometry Facility, Institute of Biotechnology, Cornell University, Ithaca, NY, USA.
Sheng ZhangProteomics & Mass Spectrometry Facility, Institute of Biotechnology, Cornell University, Ithaca, NY, USA.
Giovanni ManfrediBrain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Dmitriy ZamarinDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kevin HolcombDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
Paulo C RodriguezDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Gabriel A RabinovichLaboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
Jose R Conejo-GarciaDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Laurie H GlimcherDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA. laurie_glimcher@dfci.harvard.edu.
Juan R Cubillos-RuizWeill Cornell Graduate School of Medical Sciences, New York, NY, USA. jur2016@med.cornell.edu.
Cornell University · USMoffitt Cancer Center · USWeill Cornell Medicine · USHarvard University · USConsejo Nacional de Investigaciones Científicas y Técnicas · ARExperimental Medicine and Biology Institute · ARMemorial Sloan Kettering Cancer Center · USThe Wistar Institute · USUniversity of Virginia · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MTumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9MIMMUNOBIOLOGY OF NORMAL AND NEOPLASTIC LYMPHOCYTEST32CA009140 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Malay Haldar, WARREN S PEAR · 1985 to 2026
$16.1MT-bet and Tumor ImmunityR01CA112663 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI GLIMCHER, LAURIE HOLLIS · 2005 to 2015
$3.3MStress Pathways in Tumors Drive Global MDSC Activity and Survival through ChopR01CA184185 · NCI · LSU HEALTH SCIENCES CENTER · PI RODRIGUEZ, PAULO CESAR · 2015 to 2019
$1.8MIntegrative Approach to Comprehensive Analysis of High Throughput Data on a Cancer Center LevelR50CA211199 · NCI · WISTAR INSTITUTE · PI Andrew V Kossenkov · 2016 to 2026
$1.6MAcquisition of a Hybrid Quadrupole Time of Flight LC-MS/MS System for the CornellS10OD017992 · OD · CORNELL UNIVERSITY · PI ZHANG, SHENG · 2014 to 2014
$600kNCI NIH HHS P30 CA008748NCI NIH HHS P30 CA010815NCI NIH HHS R01 CA112663NCI NIH HHS R01 CA184185NCI NIH HHS R50 CA211199NCI NIH HHS T32 CA009140NIH HHS 1S10 OD017992-01NIH HHS S10 OD017992
Abstract
Tumours evade immune control by creating hostile microenvironments that perturb T cell metabolism and effector function
Indexed as
Amino Acid Transport Systems, BasicAnimalsAscitesCell RespirationDisease ProgressionEndoplasmic Reticulum StressEndoribonucleasesFemaleGene Expression Regulation, NeoplasticGlucoseGlutamineGlycosylationHumansInterferon-gammaMiceMitochondriaAmino Acid Transport Systems, BasicEndoribonucleasesERN1 protein, humanGlucoseGlutamineIFNG protein, humanInterferon-gammaProtein Serine-Threonine KinasesX-Box Binding Protein 1XBP1 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.