Evidence map›Paper›PMID 30305711›Full record

ArticleNature reviews. Neuroscience2018

Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing.

Roberto Cabeza, Marilyn Albert, Sylvie Belleville, Fergus I M Craik, Audrey Duarte, Cheryl L Grady, Ulman Lindenberger, Lars Nyberg, Denise C Park, Patricia A Reuter-Lorenz and 3 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature reviews. Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 622 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
622citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

622 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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562 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Roberto CabezaCenter for Cognitive Neuroscience, Department of Psychology and Neuroscience, Duke University, Durham, NC, USA. cabeza@duke.edu.
Marilyn AlbertDepartments of Psychiatry and Neurology, John Hopkins University, Baltimore, MD, USA.
Sylvie BellevilleResearch Center of the Institut Universitaire de Gériatrie de Montréal, Montreal, Quebec, Canada.
Fergus I M CraikRotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.
Audrey DuarteSchool of Psychology, Georgia Tech, Atlanta, GA, USA.
Cheryl L GradyRotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.
Ulman LindenbergerMax Planck Institute for Human Development and Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany.
Lars NybergDepartments of Radiation Sciences and Integrated Medical Biology, UFBI, Umeå University, Umeå, Sweden.
Denise C ParkCenter for Vital Longevity, University of Texas, Dallas, TX, USA.
Patricia A Reuter-LorenzDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Michael D RuggCenter for Vital Longevity, University of Texas, Dallas, TX, USA.
Jason SteffenerInterdisciplinary School of Health Sciences, University of Ottawa, Ottowa, Ontario, Canada.
M Natasha RajahDepartments of Psychiatry & Psychology, McGill University and Douglas Hospital Research Centre, Montreal, Quebec, Canada.

Funding

Dallas Lifespan Brain Study-Wave 3: Neurodegeneration & Resilience in CognitionRF1AG006265 · NIA · UNIVERSITY OF TEXAS DALLAS · PI PARK, DENISE CORTIS · 2017 to 2019
$7.1M
Relationship Between Neural Correlates of Episodic Memory,Age, Memory PerformanceRF1AG039103 · NIA · UNIVERSITY OF TEXAS DALLAS · PI RUGG, MICHAEL D · 2017 to 2017
$2.7M
CIHRNIA NIH HHS RF1 AG006265NIA NIH HHS RF1 AG039103
6 · The paper itself

Abstract

Cognitive ageing research examines the cognitive abilities that are preserved and/or those that decline with advanced age. There is great individual variability in cognitive ageing trajectories. Some older adults show little decline in cognitive ability compared with young adults and are thus termed 'optimally ageing'. By contrast, others exhibit substantial cognitive decline and may develop dementia. Human neuroimaging research has led to a number of important advances in our understanding of the neural mechanisms underlying these two outcomes. However, interpreting the age-related changes and differences in brain structure, activation and functional connectivity that this research reveals is an ongoing challenge. Ambiguous terminology is a major source of difficulty in this venture. Three terms in particular - compensation, maintenance and reserve - have been used in a number of different ways, and researchers continue to disagree about the kinds of evidence or patterns of results that are required to interpret findings related to these concepts. As such inconsistencies can impede progress in both theoretical and empirical research, here, we aim to clarify and propose consensual definitions of these terms.

Indexed as

BrainCognitive AgingCognitive NeuroscienceCognitive ReserveHealthy AgingHumans

Identifiers

PMID30305711
PMCPMC6472256

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.