Evidence map›Paper›PMID 30305701›Full record

ReviewNature reviews. Rheumatology2018

Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management.

Michelle Marshall, Fiona E Watt, Tonia L Vincent, Krysia Dziedzic

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Rheumatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed, 8 pooled it
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

128 citing papers in PubMed, 8 syntheses or guidelines pooled it, 222 citations in OpenAlex.

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  5. A meta-analysis of the therapeutic effect of total knee replacement after knee arthroscopic surgery.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2025
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68 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Michelle MarshallResearch Institute for Primary Care and Health Sciences, Arthritis Research UK Primary Care Centre, David Weatherall Building, Keele University, Keele, UK.
Fiona E WattArthritis Research UK Centre for Osteoarthritis Pathogenesis, Kennedy Institute of Rheumatology, University of Oxford, Nuffield Department of Orthopaedics,Rheumatology and Musculoskeletal Sciences (NDORMS), Oxford, UK.
Tonia L VincentArthritis Research UK Centre for Osteoarthritis Pathogenesis, Kennedy Institute of Rheumatology, University of Oxford, Nuffield Department of Orthopaedics,Rheumatology and Musculoskeletal Sciences (NDORMS), Oxford, UK.
Krysia DziedzicResearch Institute for Primary Care and Health Sciences, Arthritis Research UK Primary Care Centre, David Weatherall Building, Keele University, Keele, UK. k.s.dziedzic@keele.ac.uk.
Keele University · GBNuffield Orthopaedic Centre · GBUniversity of Oxford · GB

Funding

Department of Health CAT CDRF 10-018Department of Health KMRF-2014-03-002Department of Health PB-PG-0416-20023Department of Health RP-PG-0407-10386
6 · The paper itself

Abstract

Osteoarthritis (OA) is a highly prevalent condition, and the hand is the most commonly affected site. Patients with hand OA frequently report symptoms of pain, functional limitations and frustration in undertaking everyday activities. The condition presents clinically with changes to the bone, ligaments, cartilage and synovial tissue, which can be observed using radiography, ultrasonography or MRI. Hand OA is a heterogeneous disorder and is considered to be multifactorial in aetiology. This Review provides an overview of the epidemiology, presentation and burden of hand OA, including an update on hand OA imaging (including the development of novel techniques), disease mechanisms and management. In particular, areas for which new evidence has substantially changed the way we understand, consider and treat hand OA are highlighted. For example, genetic studies, clinical trials and careful prospective imaging studies from the past 5 years are beginning to provide insights into the pathogenesis of hand OA that might uncover new therapeutic targets in the disease.

Indexed as

Anti-Inflammatory AgentsClinical Trials as TopicDisease ManagementGenetic Predisposition to DiseaseHandHumansMagnetic Resonance ImagingOsteoarthritisPhenotypeTreatment OutcomeUltrasonographyAnti-Inflammatory Agents

Identifiers

PMID30305701
OpenAlexW2897749763

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.