Evidence map›Paper›PMID 30305637›Full record

ArticleNature communications2018

Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenström macroglobulinemia.

Mary L McMaster, Sonja I Berndt, Jianqing Zhang, Susan L Slager, Shengchao Alfred Li, Claire M Vajdic, Karin E Smedby, Huihuang Yan, Brenda M Birmann, Elizabeth E Brown and 71 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

81 authors at 20 institutions in 16 countries.

Mary L McMasterDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, 20892, MD, USA. Mary.McMaster@nih.hhs.gov.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, 20892, MD, USA.
Jianqing ZhangDepartment of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, 35233, AL, USA.ORCID http://orcid.org/0000-0001-5246-3371
Susan L SlagerDepartment of Health Sciences Research, Mayo Clinic, Rochester, 55905, MN, USA.
Shengchao Alfred LiCancer Genomics Research Laboratory, Leidos Biomedical Research, Inc., Frederick National Lab for Cancer Research, Frederick, 20877, MD, USA.
Claire M VajdicCentre for Big Data Research in Health, University of New South Wales, Sydney, 2052, NSW, Australia.ORCID http://orcid.org/0000-0002-3612-8298
Karin E SmedbyDepartment of Medicine, Solna Karolinska Institutet, Stockholm, 17176, Sweden.
Huihuang YanDepartment of Health Sciences Research, Mayo Clinic, Rochester, 55905, MN, USA.ORCID http://orcid.org/0000-0003-0756-2922
Brenda M BirmannChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, 02115, MA, USA.
Elizabeth E BrownDepartment of Pathology, University of Alabama at Birmingham, Birmingham, 35233, AL, USA.
Alex SmithDepartment of Health Sciences, University of York, York, YO10 5DD, UK.
Geffen KleinsternDepartment of Health Sciences Research, Mayo Clinic, Rochester, 55905, MN, USA.
Mervin M FanslerTri-Institutional Training Program in Computational Biology and Medicine, Weill Cornell Graduate College, New York, 10021, NY, USA.
Christine MayrCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.ORCID http://orcid.org/0000-0002-7084-7608
Bin ZhuCancer Genomics Research Laboratory, Leidos Biomedical Research, Inc., Frederick National Lab for Cancer Research, Frederick, 20877, MD, USA.
Charles C ChungCancer Genomics Research Laboratory, Leidos Biomedical Research, Inc., Frederick National Lab for Cancer Research, Frederick, 20877, MD, USA.
Ju-Hyun ParkDepartment of Statistics, Dongguk University, Seoul, 100-715, Republic of Korea.
Laurie BurdetteCancer Genomics Research Laboratory, Leidos Biomedical Research, Inc., Frederick National Lab for Cancer Research, Frederick, 20877, MD, USA.
Belynda D HicksCancer Genomics Research Laboratory, Leidos Biomedical Research, Inc., Frederick National Lab for Cancer Research, Frederick, 20877, MD, USA.
Amy HutchinsonCancer Genomics Research Laboratory, Leidos Biomedical Research, Inc., Frederick National Lab for Cancer Research, Frederick, 20877, MD, USA.
Lauren R TerasEpidemiology Research Program, American Cancer Society, Atlanta, 30303, GA, USA.
Hans-Olov AdamiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 17177, Sweden.
Paige M BracciDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, 94118, CA, USA.
James McKayInternational Agency for Research on Cancer (IARC), Lyon, 69372, France.
Alain MonnereauEpidemiology of Childhood and Adolescent Cancers Group, Inserm, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, F-94807, France.
Brian K LinkDepartment of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, 52242, IA, USA.
Roel C H VermeulenInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, 3508 TD, The Netherlands.
Stephen M AnsellDepartment of Internal Medicine, Mayo Clinic, Rochester, 55905, MN, USA.
Ann MariaDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.
W Ryan DiverEpidemiology Research Program, American Cancer Society, Atlanta, 30303, GA, USA.ORCID http://orcid.org/0000-0002-5418-9000
Mads MelbyeDivision of Health Surveillance and Research, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, 2300, Denmark.
Akinyemi I OjesinaDepartment of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, 35233, AL, USA.
Peter KraftDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 02115, MA, USA.
Paolo BoffettaThe Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.
Jacqueline ClavelEpidemiology of Childhood and Adolescent Cancers Group, Inserm, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, F-94807, France.
Edward GiovannucciChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, 02115, MA, USA.
Caroline M BessonService d'hématologie et Oncologie, Centre Hospitalier de Versailles, Le Chesnay, Inserm U1018, Centre pour la Recherche en Epidémiologie et Santé des Populations (CESP), Villejuif, 78157, France.
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.ORCID http://orcid.org/0000-0002-4261-4583
Ruth C TravisCancer Epidemiology Unit, University of Oxford, Oxford, OX3 7LF, UK.
Paolo VineisMRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, W2 1PG, UK.
Elisabete WeiderpassDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 17177, Sweden.ORCID http://orcid.org/0000-0003-2237-0128
Rebecca MontalvanWestat, Rockville, 20850, MD, USA.
Zhaoming WangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, 38105, TN, USA.
Meredith YeagerCancer Genomics Research Laboratory, Leidos Biomedical Research, Inc., Frederick National Lab for Cancer Research, Frederick, 20877, MD, USA.
Nikolaus BeckerDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, 69120, Baden-Württemberg, Germany.
Yolanda BenaventeCancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, 08908, Spain.
Paul BrennanInternational Agency for Research on Cancer (IARC), Lyon, 69372, France.ORCID http://orcid.org/0000-0002-0518-8714
Lenka ForetovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, Brno, 65653, Czech Republic.
Marc MaynadieEA 4184, Registre des Hémopathies Malignes de Côte d'Or, University of Burgundy and Dijon University Hospital, Dijon, 21070, France.
Alexandra NietersCenter for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, 79108, Baden-Württemberg, Germany.
Silvia de SanjoseCancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, 08908, Spain.
Anthony StainesSchool of Nursing and Human Sciences, Dublin City University, Dublin, 9, Ireland.ORCID http://orcid.org/0000-0001-9161-1357
Lucia CondeBill Lyons Informatics Centre, UCL Cancer Institute, University College London, London, WC1E 6DD, UK.
Jacques RibyDepartment of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, 35233, AL, USA.
Bengt GlimeliusDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, 75105, Sweden.
Henrik HjalgrimDivision of Health Surveillance and Research, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, 2300, Denmark.
Nisha PradhanDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.ORCID http://orcid.org/0000-0003-2777-4682
Andrew L FeldmanDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, 55905, MN, USA.ORCID http://orcid.org/0000-0001-5009-4808
Anne J NovakDepartment of Internal Medicine, Mayo Clinic, Rochester, 55905, MN, USA.
Charles LawrenceWestat, Rockville, 20850, MD, USA.
Bryan A BassigDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, 20892, MD, USA.
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, 20892, MD, USA.
Tongzhang ZhengDepartment of Epidemiology, Brown University, Providence, 02903, RI, USA.
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, 27599, NC, USA.
Lesley F TinkerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, 98117, WA, USA.ORCID http://orcid.org/0000-0003-2469-1929
Wendy CozenDepartment of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, 90033, CA, USA.
Richard K SeversonDepartment of Family Medicine and Public Health Sciences, Wayne State University, Detroit, 48201, MI, USA.
Jonathan N HofmannDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, 20892, MD, USA.
Yawei ZhangDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, 06520, CT, USA.
Rebecca D JacksonDivision of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, 43210, OH, USA.
Lindsay M MortonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, 20892, MD, USA.
Mark P PurdueDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, 20892, MD, USA.
Nilanjan ChatterjeeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, 20892, MD, USA.
Kenneth OffitDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.
James R CerhanDepartment of Health Sciences Research, Mayo Clinic, Rochester, 55905, MN, USA.ORCID http://orcid.org/0000-0002-7482-178X
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, 20892, MD, USA.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, 20892, MD, USA.
Joseph VijaiDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.ORCID http://orcid.org/0000-0002-7933-151X
Lynn R GoldinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, 20892, MD, USA.
Christine F SkibolaDepartment of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, 30322, GA, USA.
Neil E CaporasoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, 20892, MD, USA.
National Cancer Institute · USLeidos (United States) · USMemorial Sloan Kettering Cancer Center · USMayo Clinic in Florida · USUniversity of Alabama at Birmingham · USMayo Clinic in Arizona · USAmerican Cancer Society · USBrigham and Women's Hospital · USCentre international de recherche sur le cancer · FRDélégation Paris 5 · FRGerman Cancer Research Center · DEHarvard University · USInstitut d'Investigació Biomédica de Bellvitge · ESStatens Serum Institut · DKWestat (United States) · USBrown University · USDongguk University · KRDublin City University · IEEmory University · USFred Hutch Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
Family Studies ZIACP004410 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SAVAGE, SHARON A. · 2009 to 2025
$56.1M
The Role of Monocytes in non-Hodgkin LymphomaP50CA097274 · NCI · UNIVERSITY OF IOWA · PI WEINER, GEORGE J. · 2002 to 2021
$45.7M
Mayo Cancer Genetic Epidemiology Training ProgramR25CA092049 · NCI · MAYO CLINIC ROCHESTER · PI PETERSEN, GLORIA M., VACHON, CELINE M · 2001 to 2018
$5.3M
Genetic Epidemiology of non-Hodgkin LymphomaR01CA200703 · NCI · MAYO CLINIC ROCHESTER · PI CERHAN, JAMES R · 2016 to 2020
$3.3M
Cancer Research UK 16491CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENCI NIH HHS P30 CA008748NCI NIH HHS R01 CA200703NCI NIH HHS R25 CA092049World Health Organization 001
6 · The paper itself

Abstract

Waldenström macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is a rare, chronic B-cell lymphoma with high heritability. We conduct a two-stage genome-wide association study of WM/LPL in 530 unrelated cases and 4362 controls of European ancestry and identify two high-risk loci associated with WM/LPL at 6p25.3 (rs116446171, near EXOC2 and IRF4; OR = 21.14, 95% CI: 14.40-31.03, P = 1.36 × 10

Indexed as

Genetic Predisposition to DiseaseBase SequenceCell ProliferationChromosomes, Human, Pair 14Chromosomes, Human, Pair 6FamilyGenes, ReporterGenotyping TechniquesGreen Fluorescent ProteinsHEK293 CellsHumansInheritance PatternsMicroRNAsMolecular Sequence AnnotationPolymorphism, Single NucleotideReproducibility of Resultsenhanced green fluorescent proteinGreen Fluorescent ProteinsMicroRNAs

Identifiers

PMID30305637
PMCPMC6180091
OpenAlexW2894619040

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.