ArticleNature communications2018
Complement receptor CD46 co-stimulates optimal human CD8
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
What it found
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Who cites it
74 citing papers in PubMed, 109 citations in OpenAlex.
- CTSL loss leads to anti-PD-1 immunotherapy resistance in lung cancer by suppressing the anti-tumor function of peripheral CD8Frontiers in immunology · 2026Article
- The complement cascade in Alzheimer's disease: modern implications of an ancient immune protagonist.Molecular neurodegeneration · 2025Review
- Inside job: Roles of intracellular C3.The Journal of allergy and clinical immunology · 2025Review
- Subtype- and race-specific variations in the immune landscape of breast cancer: therapeutic implications.NPJ breast cancer · 2025Article
- Cathepsins: Emerging targets in the tumor ecosystem to overcome cancers.Seminars in cancer biology · 2025Review
- The secret life of complement: challenges and opportunities in exploring functions of the complosome in disease.The Journal of clinical investigation · 2025Review
- A CD4Immunity · 2025Article
- The multiverse of CD46 and oncologic interactions.The Journal of clinical investigation · 2025Review
- Complement activation in tumor microenvironment after neoadjuvant therapy and its impact on pancreatic cancer outcomes.NPJ precision oncology · 2025Article
- New insights into the role of complement system in colorectal cancer (Review).Molecular medicine reports · 2025Review
- An intracellular complement system drives metabolic and proinflammatory reprogramming of vascular fibroblasts in pulmonary hypertension.JCI insight · 2025Article
- GZMK-expressing CD8Nature · 2025Article
- The Complement System.Advances in experimental medicine and biology · 2025Review
- The role of complement in tumor immune tolerance and drug resistance: a double-edged sword.Frontiers in immunology · 2025Review
- Dual role of complement in neuronal repair.Frontiers in immunology · 2025Review
- Novel approach to alleviate lupus nephritis: targeting the NLRP3 inflammasome in CD8Journal of translational medicine · 2024Article
- Article
- Role of GLCCI1 in inhibiting PI3K-induced NLRP3 inflammasome activation in asthma.Chinese medical journal pulmonary and critical care medicine · 2024Article
- Canonical and non-canonical roles of complement in atherosclerosis.Nature reviews. Cardiology · 2024Review
- Functional overlap of inborn errors of immunity and metabolism genes defines T cell metabolic vulnerabilities.Science immunology · 2024Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 9 institutions in 6 countries.
Giuseppina ArboreDivision of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milano, Italy.
Erin E WestLaboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.
Jubayer RahmanLaboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.
Gaelle Le FriecSchool of Immunology and Microbial Sciences, King's College London, London, UK.
Nathalie NiyonzimaLaboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.
Mehdi PiroozniaLaboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-4210-6458
Ilker TuncLaboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.
Polychronis PavlidisSchool of Immunology and Microbial Sciences, King's College London, London, UK.
Nicholas PowellSchool of Immunology and Microbial Sciences, King's College London, London, UK.
Yuesheng LiLaboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.
Poching LiuLaboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.
Aude ServaisService de Néphrologie adulte, Hôpital Necker, Paris, France.
Lionel CouziNephrologie,Transplantation, Dialyse, CHU Bordeaux, and CNRS-UMR 5164 Immuno ConcEpT, Université de Bordeaux, Bordeaux, France.
Veronique Fremeaux-BacchiAssistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, and INSERM UMR S1138, Centre de Recherche des Cordeliers, Paris, France.
Leo PlacaisLaboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.
Alastair FerraroDepartment of Renal Medicine, Nottingham University Hospitals, NHS Trust, Nottingham, UK.
Patrick R WalshNational Renal Complement Therapeutics Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
David KavanaghNational Renal Complement Therapeutics Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
Behdad AfzaliLaboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-2968-1156
Paul LavenderSchool of Immunology and Microbial Sciences, King's College London, London, UK.
Helen J LachmannUK National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Campus, London, UK. H.lachmann@ucl.ac.uk.
Claudia KemperSchool of Immunology and Microbial Sciences, King's College London, London, UK. Claudia.kemper@nih.gov.
National Institutes of Health · USKing's College London · GBNewcastle University · GBCentre National de la Recherche Scientifique · FRHôpital Necker-Enfants Malades · FRInserm · FRNottingham University Hospitals NHS Trust · GBThe Royal Free Hospital · GBVita-Salute San Raffaele University · IT
Funding
Unravelling immunoregulatory circuits of tissue inflammationZIADK075149 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI AFZALI, BEHDAD · 2019 to 2025
$19.3MThe role of the intracellular complement system - the complosome - in Th1 biologyZIAHL006223 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KEMPER, CLAUDIA · 2017 to 2025
$16.9MBioinformatics CoreZICHL006228 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI PIROOZNIA, MEHDI · 2017 to 2021
$6.6MMedical Research Council G1002165Medical Research Council MR/J006742/1Wellcome Trust
Abstract
The induction of human CD4
Indexed as
Autocrine CommunicationCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCryopyrin-Associated Periodic SyndromesFatty AcidsHumansLymphocyte ActivationMembrane Cofactor ProteinModels, BiologicalNLR Family, Pyrin Domain-Containing 3 ProteinReceptors, Antigen, T-CellReceptors, ComplementSignal TransductionT-Lymphocytes, CytotoxicCD46 protein, humanFatty AcidsMembrane Cofactor ProteinNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanReceptors, Antigen, T-CellReceptors, Complement
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.