ArticleNature communications2018
Structural insights on TRPV5 gating by endogenous modulators.
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Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.
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103citing papers in PubMed
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Who cites it
103 citing papers in PubMed, 156 citations in OpenAlex.
- Article
- Article
- Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin.The Journal of physiology · 2026Review
- Molecular mechanism of menthol-induced TRPV5 channel inhibition.Nature communications · 2026Article
- Perspectives on TRPV Channels in the Structural and Computational Revolution Era.Advances in experimental medicine and biology · 2026Review
- Discovery of the small molecular inhibitors against TRPV6 as potential anti-cancer agents by structural based virtual screening.Frontiers in chemistry · 2026Article
- Structural landscape of activation, desensitization and inhibition in the human TRPM4 channel.Nature structural & molecular biology · 2026Article
- A novel small molecule NJH-13 induces pyroptosis via the CaJournal of advanced research · 2025Article
- Physiological functions and pharmacological targeting of transient receptor potential channels.Pharmacological reviews · 2025Review
- Calmodulin binding is required for calcium mediated TRPA1 desensitization.Nature communications · 2025Article
- PIP2 regulation of TRPV4 channels: Binding sites and dynamic coupling.Biophysical journal · 2025Article
- Suyin Detoxification Prescription Regulates the Klotho and ERK/NF-κB Signaling Pathways to Alleviate Renal Injury.Cell biochemistry and biophysics · 2025Article
- Mitochondrial Transport Proteins in Cardiovascular Diseases: Metabolic Gatekeepers, Pathogenic Mediators and Therapeutic Targets.International journal of molecular sciences · 2025Review
- Molecular basis of TRPV3 channel blockade by intracellular polyamines.Communications biology · 2025Article
- Effects of Graphene Quantum Dots on Renal Fibrosis Through Alleviating Oxidative Stress and Restoring Mitochondrial Membrane Potential.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The Influence of Phosphoinositide Lipids in the Molecular Biology of Membrane Proteins: Recent Insights from Simulations.Journal of molecular biology · 2025Review
- Forty sites of TRP channel regulation.Current opinion in chemical biology · 2025Review
- Structure-function analyses of human TRPV6 ancestral and derived haplotypes.Structure (London, England : 1993) · 2025Article
- A novel TRPV5/6-like channel from a scleractinian coral.PloS one · 2025Article
- Calmodulin regulates TRPV5 intracellular trafficking and plasma membrane abundance.The Journal of physiology · 2024Article
43 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 4 institutions in 1 country.
Taylor E T HughesDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0002-6064-1227
Ruth A PumroyDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0002-6200-6083
Aysenur Torun YaziciDepartment of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University, Newark, NJ, 07103, USA.ORCID http://orcid.org/0000-0002-1715-0107
Marina A KasimovaInstitute for Computational Molecular Science, Temple University, Philadelphia, PA, 19122, USA.
Edwin C FluckDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0002-7663-569X
Kevin W HuynhCalifornia NanoSystems Institute, University of California, Los Angeles, CA, 90095, USA.
Amrita SamantaDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Sudheer K MoluguDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Z Hong ZhouCalifornia NanoSystems Institute, University of California, Los Angeles, CA, 90095, USA.
Vincenzo CarnevaleInstitute for Computational Molecular Science, Temple University, Philadelphia, PA, 19122, USA.ORCID http://orcid.org/0000-0002-1918-8280
Tibor RohacsDepartment of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University, Newark, NJ, 07103, USA.
Vera Y Moiseenkova-BellDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. vmb@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-0589-4053
Translational Therapeutics (United States) · USCalifornia NanoSystems Institute · USRutgers, The State University of New Jersey · USTemple University · US
Funding
X-ray and Neutron Interferometry Studies of Anesthetic Interactions with VoltageP01GM055876 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI ECKENHOFF, RODERIC G · 1997 to 2017
$22.4MTISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7MRegulation of sensory TRP channels by phospholipids and G-proteinsR01NS055159 · NINDS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI ROHACS, TIBOR · 2007 to 2022
$5.9MRegulation of the Intestinal Ca2+ Channels TRPV6R01GM093290 · NIGMS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI CARNEVALE, VINCENZO, ROHACS, TIBOR · 2011 to 2025
$4.9MIn situ atomic structures of the Kaposi's sarcoma-associated herpesvirus portal-terminase complex and glycoproteinsR01DE025567 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WU, TING-TING, ZHOU, Z HONG · 2016 to 2024
$4.0MStructural Insights into TRPV Channel GatingR01GM103899 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MOISEENKOVA-BELL, VERA · 2013 to 2021
$3.2MWest/Midwest Consortium for High-Resolution Cryo Electron MicroscopyU24GM116792 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AGBANDJE-MCKENNA, MAVIS, DOKLAND, TERJE · 2016 to 2020
$3.0MMolecular mechanisms of TRPV5 gatingR01GM129357 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MOISEENKOVA-BELL, VERA · 2018 to 2021
$1.7MHIGH-END CRYOEM INSTRUMENT FOR UCLA ELECTRON IMAGING CTR FOR NANOMACHINES: AIDSS10RR023057 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHOU, Z HONG · 2006 to 2006
$1.6MMolecular mechanism of TRPV1 activationR01GM131048 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI CARNEVALE, VINCENZO, ROHACS, TIBOR · 2019 to 2022
$1.4MDirect Detection Device for atomic resolution cryoEM of macromolecular complexesS10OD018111 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHOU, Z HONG · 2014 to 2014
$598kNCRR NIH HHS S10 RR023057NEI NIH HHS P30 EY011373NIDCR NIH HHS R01 DE025567NIGMS NIH HHS P01 GM055876NIGMS NIH HHS R01 GM093290NIGMS NIH HHS R01 GM103899NIGMS NIH HHS R01 GM129357NIGMS NIH HHS R01 GM131048NIGMS NIH HHS U24 GM116792NIH HHS S10 OD018111NINDS NIH HHS R01 NS055159U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM093290U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM103899
Abstract
TRPV5 is a transient receptor potential channel involved in calcium reabsorption. Here we investigate the interaction of two endogenous modulators with TRPV5. Both phosphatidylinositol 4,5-bisphosphate (PI(4,5)P
Indexed as
Ion Channel GatingAnimalsCalmodulinModels, BiologicalModels, MolecularPhosphatidylinositol 4,5-DiphosphateRabbitsStructure-Activity RelationshipTRPV Cation ChannelsCalmodulinPhosphatidylinositol 4,5-DiphosphateTRPV Cation Channels
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