ArticleNature communications2018
Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 65 citations in OpenAlex.
- L-arabinose: a strategic modulator of pathogen virulence for food system safety.Archives of microbiology · 2026Review
- An inflammasome-driven differentiation program in intestinal stem cells protects against Salmonella infection.Nature immunology · 2026Article
- Bacterial metabolic remodeling by convergent evolution unlocks nutrient availability after a host switch.Science advances · 2026Article
- Perturbing H-NS function reveals roles in restricting virulence heterogeneity and pathogen adaptation.bioRxiv : the preprint server for biology · 2026Article
- Gut microbiome-derived indoles differentially suppress type III secretion system-associated virulence inFrontiers in microbiology · 2026Article
- Anoxia activates CRISPR-Cas immunity in the mouse intestine.Nature microbiology · 2025Article
- Convergent evolution of distinct D-ribulose utilisation pathways in attaching and effacing pathogens.Nature communications · 2025Article
- Transcriptional diversification in a human-adapting zoonotic pathogen drives niche-specific evolution.Nature communications · 2025Article
- Enteric bacterial infection stimulates remodelling of bile metabolites to promote intestinal homeostasis.Nature microbiology · 2024Article
- A master regulator of central carbon metabolism directly activates virulence gene expression in attaching and effacing pathogens.PLoS pathogens · 2024Article
- Metabolism of L-arabinose converges with virulence regulation to promote enteric pathogen fitness.Nature communications · 2024Article
- Microbiota-mediated colonization resistance: mechanisms and regulation.Nature reviews. Microbiology · 2023Review
- Ketogenic diet protects MPTP-induced mouse model of Parkinson's disease via altering gut microbiota and metabolites.MedComm · 2023Article
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- Quantitative dose-response analysis untangles host bottlenecks to enteric infection.Nature communications · 2023Article
- Distinct ecological fitness factors coordinated by a conservedProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Effects of second-line anti-tuberculosis drugs on the intestinal microbiota of patients with rifampicin-resistant tuberculosis.Frontiers in cellular and infection microbiology · 2023Article
- Integrated Analysis of Gut Microbiome and Lipid Metabolism in Mice Infected with Carbapenem-ResistantMetabolites · 2022Article
- Biogenesis of a bacterial metabolosome for propanediol utilization.Nature communications · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Niche-adaptation of a bacterial pathogen hinges on the ability to recognize the complexity of signals from the environment and integrate that information with the regulation of genes critical for infection. Here we report the transcriptome of the attaching and effacing pathogen Citrobacter rodentium during infection of its natural murine host. Pathogen gene expression in vivo was heavily biased towards the virulence factor repertoire and was found to be co-ordinated uniquely in response to the host. Concordantly, we identified the host-specific induction of a metabolic pathway that overlapped with the regulation of virulence. The essential type 3 secretion system and an associated suite of distinct effectors were found to be modulated co-ordinately through a unique mechanism involving metabolism of microbiota-derived 1,2-propanediol, which dictated the ability to colonize the host effectively. This study provides novel insights into how host-specific metabolic adaptation acts as a cue to fine-tune virulence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.