Evidence map›Paper›PMID 30305604›Full record

ArticleCell death & disease2018

Diosgenin promotes antitumor immunity and PD-1 antibody efficacy against melanoma by regulating intestinal microbiota.

Mengxue Dong, Zhefeng Meng, Kudelaidi Kuerban, Feilong Qi, Jiayang Liu, Yuxi Wei, Qian Wang, Shanshan Jiang, Meiqing Feng, Li Ye

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 108 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. The microbiota-gut-brain axis: a potential target in the small-molecule compounds and gene therapeutic strategies for Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  18. Review
  19. Frontiers in plant science · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Mengxue DongDepartment of Microbiological & Biochemical Pharmacy, School of Pharmacy, Fudan University, 201203, Shanghai, China.
Zhefeng MengMinhang Branch, Zhongshan Hospital, Fudan University, 201199, Shanghai, China.
Kudelaidi KuerbanDepartment of Microbiological & Biochemical Pharmacy, School of Pharmacy, Fudan University, 201203, Shanghai, China.
Feilong QiDepartment of Microbiological & Biochemical Pharmacy, School of Pharmacy, Fudan University, 201203, Shanghai, China.
Jiayang LiuDepartment of Microbiological & Biochemical Pharmacy, School of Pharmacy, Fudan University, 201203, Shanghai, China.
Yuxi WeiDepartment of Microbiological & Biochemical Pharmacy, School of Pharmacy, Fudan University, 201203, Shanghai, China.
Qian WangDepartment of Microbiological & Biochemical Pharmacy, School of Pharmacy, Fudan University, 201203, Shanghai, China.
Shanshan JiangDepartment of Pharmacy, Shanghai Ninth People' s Hospital, Shanghai Jiao Tong University School of Medicine, 200011, Shanghai, China.
Meiqing FengDepartment of Microbiological & Biochemical Pharmacy, School of Pharmacy, Fudan University, 201203, Shanghai, China.
Li YeDepartment of Microbiological & Biochemical Pharmacy, School of Pharmacy, Fudan University, 201203, Shanghai, China. yelil@fudan.edu.cn.
Fudan University · CNShanghai Jiao Tong University · CNZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diosgenin, a natural steroidal saponin, can exert antitumor effect by regulating immune function and improving intestinal microbiota. The response to anti-PD-1 immunotherapy is associated with intestinal microbiota and effector T cells in tumor microenvironment. We hypothesize that the modulation of diosgenin on intestinal microbiota can facilitate antitumor immunity and the therapeutic efficacy of PD-1 antibody. In melanoma-bearing C57BL/6 mice, we observed that the anti-melanoma effect of diosgenin relied more on antitumor immunity than direct tumor inhibition activity evidenced by obvious CD4

Indexed as

AnimalsAntibodies, MonoclonalAntineoplastic AgentsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell Line, TumorDiosgeninFemaleGastrointestinal MicrobiomeImmunotherapyInterferon-gammaMelanomaMiceMice, Inbred BALB CMice, Inbred C57BLProgrammed Cell Death 1 ReceptorAntibodies, MonoclonalAntineoplastic AgentsDiosgeninInterferon-gammaPdcd1 protein, mouseProgrammed Cell Death 1 Receptor

Identifiers

PMID30305604
PMCPMC6179990
OpenAlexW2897022305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.