Evidence map›Paper›PMID 30305450›Full record

Observational studyNeurology2018

Gray matter differences in patients with functional movement disorders.

Carine W Maurer, Kathrin LaFaver, Gaurang S Limachia, Geanna Capitan, Rezvan Ameli, Stephen Sinclair, Steven A Epstein, Mark Hallett, Silvina G Horovitz

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
  2. Imaging biomarkers in functional neurological disorders.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Mark Hallett and the renaissance of functional neurological disorder.Clinical parkinsonism & related disorders · 2026
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Long COVID Is Not a Functional Neurologic Disorder.Journal of personalized medicine · 2024
    Review
  17. Review
  18. Article
  19. Dysfunctional Networks in Functional Dystonia.Advances in neurobiology · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Carine W MaurerFrom the Human Motor Control Section, Medical Neurology Branch (C.W.M., K.L., G.S.L., G.C., M.H., S.G.H.), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD; Department of Neurology (C.W.M.), Stony Brook University School of Medicine, NY; Department of Neurology (K.L.), University of Louisville, KY; Experimental Therapeutics and Pathophysiology Branch (R.A.) and Office of the Clinical Director (S.S.), National Institute of Mental Health, NIH, Bethesda, MD; and Department of Psychiatry (S.A.E.), Georgetown University, Washington, DC. carine.maurer@stonybrookmedicine.edu.
Kathrin LaFaverFrom the Human Motor Control Section, Medical Neurology Branch (C.W.M., K.L., G.S.L., G.C., M.H., S.G.H.), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD; Department of Neurology (C.W.M.), Stony Brook University School of Medicine, NY; Department of Neurology (K.L.), University of Louisville, KY; Experimental Therapeutics and Pathophysiology Branch (R.A.) and Office of the Clinical Director (S.S.), National Institute of Mental Health, NIH, Bethesda, MD; and Department of Psychiatry (S.A.E.), Georgetown University, Washington, DC.
Gaurang S LimachiaFrom the Human Motor Control Section, Medical Neurology Branch (C.W.M., K.L., G.S.L., G.C., M.H., S.G.H.), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD; Department of Neurology (C.W.M.), Stony Brook University School of Medicine, NY; Department of Neurology (K.L.), University of Louisville, KY; Experimental Therapeutics and Pathophysiology Branch (R.A.) and Office of the Clinical Director (S.S.), National Institute of Mental Health, NIH, Bethesda, MD; and Department of Psychiatry (S.A.E.), Georgetown University, Washington, DC.
Geanna CapitanFrom the Human Motor Control Section, Medical Neurology Branch (C.W.M., K.L., G.S.L., G.C., M.H., S.G.H.), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD; Department of Neurology (C.W.M.), Stony Brook University School of Medicine, NY; Department of Neurology (K.L.), University of Louisville, KY; Experimental Therapeutics and Pathophysiology Branch (R.A.) and Office of the Clinical Director (S.S.), National Institute of Mental Health, NIH, Bethesda, MD; and Department of Psychiatry (S.A.E.), Georgetown University, Washington, DC.
Rezvan AmeliFrom the Human Motor Control Section, Medical Neurology Branch (C.W.M., K.L., G.S.L., G.C., M.H., S.G.H.), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD; Department of Neurology (C.W.M.), Stony Brook University School of Medicine, NY; Department of Neurology (K.L.), University of Louisville, KY; Experimental Therapeutics and Pathophysiology Branch (R.A.) and Office of the Clinical Director (S.S.), National Institute of Mental Health, NIH, Bethesda, MD; and Department of Psychiatry (S.A.E.), Georgetown University, Washington, DC.
Stephen SinclairFrom the Human Motor Control Section, Medical Neurology Branch (C.W.M., K.L., G.S.L., G.C., M.H., S.G.H.), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD; Department of Neurology (C.W.M.), Stony Brook University School of Medicine, NY; Department of Neurology (K.L.), University of Louisville, KY; Experimental Therapeutics and Pathophysiology Branch (R.A.) and Office of the Clinical Director (S.S.), National Institute of Mental Health, NIH, Bethesda, MD; and Department of Psychiatry (S.A.E.), Georgetown University, Washington, DC.
Steven A EpsteinFrom the Human Motor Control Section, Medical Neurology Branch (C.W.M., K.L., G.S.L., G.C., M.H., S.G.H.), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD; Department of Neurology (C.W.M.), Stony Brook University School of Medicine, NY; Department of Neurology (K.L.), University of Louisville, KY; Experimental Therapeutics and Pathophysiology Branch (R.A.) and Office of the Clinical Director (S.S.), National Institute of Mental Health, NIH, Bethesda, MD; and Department of Psychiatry (S.A.E.), Georgetown University, Washington, DC.
Mark HallettFrom the Human Motor Control Section, Medical Neurology Branch (C.W.M., K.L., G.S.L., G.C., M.H., S.G.H.), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD; Department of Neurology (C.W.M.), Stony Brook University School of Medicine, NY; Department of Neurology (K.L.), University of Louisville, KY; Experimental Therapeutics and Pathophysiology Branch (R.A.) and Office of the Clinical Director (S.S.), National Institute of Mental Health, NIH, Bethesda, MD; and Department of Psychiatry (S.A.E.), Georgetown University, Washington, DC.
Silvina G HorovitzFrom the Human Motor Control Section, Medical Neurology Branch (C.W.M., K.L., G.S.L., G.C., M.H., S.G.H.), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD; Department of Neurology (C.W.M.), Stony Brook University School of Medicine, NY; Department of Neurology (K.L.), University of Louisville, KY; Experimental Therapeutics and Pathophysiology Branch (R.A.) and Office of the Clinical Director (S.S.), National Institute of Mental Health, NIH, Bethesda, MD; and Department of Psychiatry (S.A.E.), Georgetown University, Washington, DC.
National Institute of Mental Health · USStony Brook University · USUniversity of Louisville · US

Funding

Pathophysiology of Involuntary Movements and Volitional DisordersZIANS002667 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI HALLETT, MARK · 2009 to 2023
$17.7M
6 · The paper itself

Abstract

objectiveTo explore alterations in gray matter volume in patients with functional movement disorders.

methodsWe obtained T1-weighted MRI on 48 patients with clinically definite functional movement disorders, a subset of functional neurologic symptom disorder characterized by abnormal involuntary movements, and on 55 age- and sex-matched healthy controls. We compared between-group differences in gray matter volume using voxel-based morphometry across the whole brain. All participants in addition underwent a thorough neuropsychological battery, including the Hamilton Anxiety and Depression Scales and the Childhood Trauma Questionnaire. To determine whether confounding factors such as comorbid depression, anxiety, or childhood trauma exposure contributed to the observed structural changes, nonparametric correlation analysis was performed.

resultsPatients with functional movement disorders exhibited increased volume of the left amygdala, left striatum, left cerebellum, left fusiform gyrus, and bilateral thalamus, and decreased volume of the left sensorimotor cortex (whole-brain corrected

conclusionThis study demonstrates that patients with functional movement disorders exhibit structural gray matter abnormalities in critical components of the limbic and sensorimotor circuitry. These abnormalities may represent a premorbid trait rendering patients more susceptible to disease, the disease itself, or a compensatory response to disease.

Indexed as

AdultAgedBrainFemaleGray MatterHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedMovement DisordersYoung Adult

Identifiers

PMID30305450
PMCPMC6260194
OpenAlexW2897783414

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.