ArticleJournal of the Royal Society, Interface2018
Segment-specific associations between local haemodynamic and imaging markers of early atherosclerosis at the carotid artery: an
Article in Journal of the Royal Society, Interface, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Effects of Ageing on Aortic Circulation During Atrial Fibrillation; a Numerical Study on Different Aortic Morphologies.Annals of biomedical engineering · 2021Pooled it
- Prediction of Long Term Restenosis Risk After Surgery in the Carotid Bifurcation by Hemodynamic and Geometric Analysis.Annals of biomedical engineering · 2019Trial
- Hemodynamic and Geometrical Parameters Associated with Carotid Artery Stenosis: A Cross-Sectional Study Using 4D Flow MRI and CFD.Annals of biomedical engineering · 2026Article
- Data driven approach to identify vulnerable plaques in carotid atherosclerosis using computed tomography imaging and computational fluid dynamics: A pilot study.PLOS digital health · 2026Article
- Uncertainty Quantification in Hemodynamic Metrics from 4D Flow MRI with Super-resolution in a Carotid Bifurcation Model.Journal of imaging informatics in medicine · 2026Article
- Influence of wall distensibility on local hemodynamics at the normal carotid bifurcation: a fluid-structure interaction study.Biomechanics and modeling in mechanobiology · 2026Article
- Comparison of Hemodynamics After Fenestrated, Branched, and Chimney Endovascular Aneurysm Repair Employing Computational Fluid Dynamics.Journal of clinical medicine · 2026Article
- History and emerging trends of computational fluid dynamics applications in atherosclerosis: a bibliometric analysis and narrative review.Annals of medicine and surgery (2012) · 2026Review
- Phase-specific turbulence index derived from vector flow imaging for identifying intraplaque neovascularization in carotid plaques.Frontiers in cardiovascular medicine · 2026Article
- In Silico, Patient-Specific Assessment of Local Hemodynamic Predictors and Neointimal Hyperplasia Localisation in an Arteriovenous Graft.Annals of biomedical engineering · 2025Article
- Impact of Carotid Artery Geometry and Clinical Risk Factors on Carotid Atherosclerotic Plaque Prevalence.Journal of personalized medicine · 2025Article
- Anatomical Variations and Morphometry of Carotid Sinus: A Computed Tomography Study.Tomography (Ann Arbor, Mich.) · 2025Article
- Maximum admittance method for cerebrovascular outlet boundary conditions and importance of stenosis severity as a dominant factor on hemodynamics.Scientific reports · 2025Article
- Patient-Specific Numerical Simulations of Coronary Artery Hemodynamics and Biomechanics: A Pathway to Clinical Use.Cardiovascular engineering and technology · 2024Review
- The hemodynamic and geometric characteristics of carotid artery atherosclerotic plaque formation.Quantitative imaging in medicine and surgery · 2024Article
- Modulation of arterial intima stiffness by disturbed blood flow.Experimental biology and medicine (Maywood, N.J.) · 2024Article
- Time-resolved simulation of blood flow through left anterior descending coronary artery: effect of varying extent of stenosis on hemodynamics.BMC cardiovascular disorders · 2023Article
- Spiral Laminar Flow is Associated with a Reduction in Disturbed Shear in Patient-Specific Models of an Arteriovenous Fistula.Cardiovascular engineering and technology · 2023Article
- Wall shear stress and its role in atherosclerosis.Frontiers in cardiovascular medicine · 2023Review
- Carotid geometry is independently associated with complicated carotid artery plaques.Frontiers in cardiovascular medicine · 2023Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low and oscillatory wall shear stress (WSS) has long been hypothesized as a risk factor for atherosclerosis; however, evidence has been inferred primarily from model and post-mortem studies, or clinical studies of patients with already-developed plaques. This study aimed to identify associations between local haemodynamic and imaging markers of early atherosclerosis. Comprehensive magnetic resonance imaging allowed quantification of contrast enhancement (CE) (a marker of endothelial dysfunction) and vessel wall thickness at two distinct segments: the internal carotid artery bulb and the common carotid artery (CCA). Strict criteria were applied to a large dataset to exclude inward remodelling, resulting in 41 cases for which personalized computational fluid dynamic simulations were performed. After controlling for cardiovascular risk factors, bulb wall thickening was found to be weakly, but not significantly, associated with oscillatory WSS. CE at the bulb was significantly associated with low WSS (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.