Evidence map›Paper›PMID 30305396›Full record

ArticleThe Journal of biological chemistry2018

Substrate priming enhances phosphorylation by the budding yeast kinases Kin1 and Kin2.

Grace R Jeschke, Hua Jane Lou, Keith Weise, Charlotte I Hammond, Mallory Demonch, Patrick Brennwald, Benjamin E Turk

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Grace R JeschkeFrom the Department of Pharmacology, Yale School of Medicine, New Haven, Connecticut 06520.
Hua Jane LouFrom the Department of Pharmacology, Yale School of Medicine, New Haven, Connecticut 06520.
Keith WeiseFrom the Department of Pharmacology, Yale School of Medicine, New Haven, Connecticut 06520.
Charlotte I Hammondthe Department of Biology, Quinnipiac University, Hamden, Connecticut 06518, and.
Mallory Demonchthe Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina 27599.
Patrick Brennwaldthe Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina 27599.
Benjamin E TurkFrom the Department of Pharmacology, Yale School of Medicine, New Haven, Connecticut 06520,. Electronic address: ben.turk@yale.edu.
Yale University · USUniversity of North Carolina at Chapel Hill · USQuinnipiac University · US

Funding

REGULATION OF EXOCYTOSIS BY A RHO GTPPASER01GM054712 · NIGMS · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI PATRICK J BRENNWALD · 1998 to 2026
$9.5M
Modeling human phosphorylation networks through kinome-wide profilingR01GM104047 · NIGMS · YALE UNIVERSITY · PI TURK, BENJAMIN E, YAFFE, MICHAEL B · 2013 to 2017
$2.4M
Phosphorylation networks regulated by energy stress in yeastR01GM105947 · NIGMS · YALE UNIVERSITY · PI TURK, BENJAMIN E · 2013 to 2016
$1.3M
NIGMS NIH HHS R01 GM054712NIGMS NIH HHS R01 GM104047NIGMS NIH HHS R01 GM105947
6 · The paper itself

Abstract

Multisite phosphorylation of proteins is a common mechanism for signal integration and amplification in eukaryotic signaling networks. Proteins are commonly phosphorylated at multiple sites in an ordered manner, whereby phosphorylation by one kinase primes the substrate by generating a recognition motif for a second kinase. Here we show that substrate priming promotes phosphorylation by

Indexed as

Amino Acid MotifsMembrane ProteinsPeptidesPhosphorylationProtein Serine-Threonine KinasesQc-SNARE ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSubstrate SpecificityKIN1 protein, S cerevisiaeKIN2 protein, S cerevisiaeMembrane ProteinsPeptidesProtein Serine-Threonine KinasesQc-SNARE ProteinsSaccharomyces cerevisiae ProteinsSEC9 protein, S cerevisiaeendoplasmic reticulum stress (ER stress)exocytosiskinase primingphosphorecognitionprotein kinaseprotein phosphorylationSec9signal transductionSNARE proteinsyeast

Identifiers

PMID30305396
PMCPMC6254337
OpenAlexW2897145389

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.