Evidence map›Paper›PMID 30305387›Full record

ArticleJournal of clinical microbiology2018

Performance of Xpert MTB/RIF, Xpert Ultra, and Abbott RealTi

Rebecca H Berhanu, Anura David, Pedro da Silva, Kate Shearer, Ian Sanne, Wendy Stevens, Lesley Scott

Open access · bronzeAbstract readEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 4 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Evaluating the efficacy of stool sample on Xpert MTB/RIF Ultra and its comparison with other sample types by meta-analysis for TB diagnostics.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Clinical performance of the Abbott RealTime Mycobacterium tuberculosis (MTB) PCR on bronchoscopic specimens for diagnosing pulmonary tuberculosis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
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  8. Observational
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  19. Pooling Sputum Samples for Efficient Mass Tuberculosis Screening in Prisons.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Rebecca H BerhanuHealth Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa rberhanu@heroza.org.ORCID 0000-0002-9692-8748
Anura DavidNational Priority Program, National Health Laboratory Service, Johannesburg, South Africa.
Pedro da SilvaNational Priority Program, National Health Laboratory Service, Johannesburg, South Africa.
Kate ShearerHealth Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Ian SanneHealth Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Wendy Stevens *National Priority Program, National Health Laboratory Service, Johannesburg, South Africa.
Lesley Scott *Department of Molecular Medicine and Haematology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
National Health Laboratory Service · ZAUniversity of the Witwatersrand · ZAJohns Hopkins University · US

Funding

UJMT – ORWH – Gazzetta, Issa-BoubeD43TW009340 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI William Checkley, Benjamin H. Chi · 2017 to 2026
$14.8M
Fogarty Global Health Fellows Coordinating CenterR25TW009340 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHI, BENJAMIN H. · 2012 to 2016
$6.9M
BU Clinical HIV/AIDS Research Training Program (BU-CHART)T32AI052074 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Benjamin P. Linas · 2003 to 2026
$6.7M
FIC NIH HHS D43 TW009340FIC NIH HHS R25 TW009340Medical Research Council MC_PC_16021NIAID NIH HHS T32 AI052074
6 · The paper itself

Abstract

More sensitive tests are needed for the diagnosis of smear-negative and HIV-associated tuberculosis. This study compares the sensitivities and specificities of three molecular tests, namely, the Xpert MTB/RIF test, the Xpert Ultra (Ultra), and RealTi

Indexed as

AdolescentAdultAgedAIDS-Related Opportunistic InfectionsCD4 Lymphocyte CountDiagnostic Tests, RoutineFemaleHumansMaleMiddle AgedMolecular Diagnostic TechniquesMycobacterium tuberculosisReference StandardsSensitivity and SpecificitySouth AfricaSputumAbbott RealTime MTBmolecular diagnosticsSouth AfricatuberculosisXpert MTB/RIFXpert Ultra

Identifiers

PMID30305387
PMCPMC6258835
OpenAlexW2903551807

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.