Evidence map›Paper›PMID 30305354›Full record

ArticleJournal of virology2019

Genotypic and Mechanistic Characterization of Subtype-Specific HIV Adaptation to Host Cellular Immunity.

Natalie N Kinloch, Guinevere Q Lee, Jonathan M Carlson, Steven W Jin, Chanson J Brumme, Helen Byakwaga, Conrad Muzoora, Mwebesa B Bwana, Kyle D Cobarrubias, Peter W Hunt and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 20 citations in OpenAlex.

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  14. The advances in pyroptosis initiated by inflammasome in inflammatory and immune diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 3 countries.

Natalie N KinlochFaculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
Guinevere Q LeeRagon Institute of Massachusetts General Hospital, MIT and Harvard, Cambridge, Massachusetts, USA.
Jonathan M CarlsonMicrosoft Research, Seattle, Washington, USA.
Steven W JinFaculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
Chanson J BrummeBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
Helen ByakwagaMbarara University of Science and Technology, Mbarara, Uganda.
Conrad MuzooraMbarara University of Science and Technology, Mbarara, Uganda.
Mwebesa B BwanaMbarara University of Science and Technology, Mbarara, Uganda.
Kyle D CobarrubiasFaculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
Peter W HuntUniversity of California, San Francisco, San Francisco, California, USA.
Jeff N MartinUniversity of California, San Francisco, San Francisco, California, USA.
Mary CarringtonCancer and Inflammation Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
David R BangsbergOregon Health and Science University-Portland State University School of Public Health, Portland, Oregon, USA.
P Richard HarriganDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Mark A BrockmanFaculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.ORCID 0000-0001-6432-1426
Zabrina L BrummeFaculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada zbrumme@sfu.ca.ORCID 0000-0002-8157-1037
Simon Fraser University · CAMbarara University of Science and Technology · UGUniversity of California, San Francisco · USAIDS Vancouver · CAFrederick National Laboratory for Cancer Research · USMicrosoft (United States) · USPortland State University · USRagon Institute of MGH, MIT and Harvard · USUniversity of British Columbia · CA

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 1988 to 2026
$93.6M
Molecular genetics and population studies of the KIR and HLA gene complexesZIABC010792 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CARRINGTON, MARY N. · 2009 to 2025
$7.8M
CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENIAID NIH HHS P30 AI027763
6 · The paper itself

Abstract

The extent to which viral genetic context influences HIV adaptation to human leukocyte antigen (HLA) class I-restricted immune pressures remains incompletely understood. The Ugandan HIV epidemic, where major pandemic group M subtypes A1 and D cocirculate in a single host population, provides an opportunity to investigate this question. We characterized plasma HIV RNA

Indexed as

AIDS Vaccinesgag Gene Products, Human Immunodeficiency VirusGenotypeGenotyping TechniquesHIV-1HIV InfectionsHLA AntigensHuman Immunodeficiency Virus ProteinsHumansImmune EvasionImmunity, Cellularnef Gene Products, Human Immunodeficiency VirusPhylogenypol Gene Products, Human Immunodeficiency VirusPolymorphism, GeneticUgandaAIDS Vaccinesgag Gene Products, Human Immunodeficiency VirusHLA AntigensHuman Immunodeficiency Virus Proteinsnef Gene Products, Human Immunodeficiency Viruspol Gene Products, Human Immunodeficiency VirusadaptationCTLepitopeevolutionHLAhuman immunodeficiency virusimmune escapesubtypeUganda

Identifiers

PMID30305354
PMCPMC6288327
OpenAlexW2903767004

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.