ArticleDiabetes care2018
Fasting Glucose Variability in Young Adulthood and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.
Article in Diabetes care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed.
- Midlife depressive symptoms, smoking status, hypertension, diabetes, dyslipidemia and obesity modify the association of long-term vascular risk factor variability from childhood with midlife cognitive function: The Bogalusa Heart Study.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Association of Long-Term Vascular Risk Factor Variability from Childhood and Midlife Cognitive Function: The Bogalusa Heart Study.Research square · 2026Article
- Association of glycemic variability with the risk of new-onset atrial fibrillation and death in critically ill patients without diabetes: analysis of the MIMIC-IV database.Diabetology & metabolic syndrome · 2026Article
- Vascular risk factor variability and cognitive impairment in older adults a community-based retrospective study.Scientific reports · 2025Article
- Cardiovascular Health Trajectories and Prevalent Metabolic Dysfunction-Associated Steatotic Liver Disease in Midlife: The CARDIA Study.Journal of the American Heart Association · 2025Article
- Trajectories of Sleep Duration, Sleep Onset Timing, and Continuous Glucose Monitoring in Adults.JAMA network open · 2025Article
- Associations of Neighborhood Food and Physical Activity Environments in Young Adulthood With Cardiovascular Health in Midlife: The CARDIA Study.Journal of the American Heart Association · 2024Article
- Increased Risk of Alzheimer's Disease With Glycemic Variability: A Systematic Review and Meta-Analysis.Cureus · 2024Review
- Association of Glycemic Variability With Imaging Markers of Vascular Burden, β-Amyloid, Brain Atrophy, and Cognitive Impairment.Neurology · 2024Article
- Visit-to-visit variability in multiple biological measurements and cognitive performance and risk of cardiovascular disease: A cohort study.Cerebral circulation - cognition and behavior · 2024Article
- Visit-to-Visit Glucose Variability, Cognition, and Global Cognitive Decline: The Multi-Ethnic Study of Atherosclerosis.The Journal of clinical endocrinology and metabolism · 2023Article
- Fasting glucose variability and risk of dementia in Parkinson's disease: a 9-year longitudinal follow-up study of a nationwide cohort.Frontiers in aging neuroscience · 2023Article
- Pulmonary Function in Midlife as a Predictor of Later-Life Cognition: The Coronary Artery Risk Development in Adults (CARDIA) Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Risk Factors for Incident Coronary Artery Calcium in Younger (Age 32 to 45 Years) Versus Intermediate (46 to 64 Years) Versus Older (65 to 84 Years) Persons.The American journal of cardiology · 2022Article
- Association between visit-to-visit fasting glycemic variability and depression: a retrospective cohort study in a representative Korean population without diabetes.Scientific reports · 2022Article
- Fasting Glucose Variability and the Risk of Dementia in Individuals with Diabetes: A Nationwide Cohort Study.Diabetes & metabolism journal · 2022Article
- Magnesium intake is inversely associated with risk of non-alcoholic fatty liver disease among American adults.European journal of nutrition · 2022Article
- Relationship of fasting glucose and longitudinal Alzheimer's disease imaging markers.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Visit-to-visit fasting blood glucose variability and lifetime risk of cardiovascular disease: a prospective study.Cardiovascular diabetology · 2021Observational
- Calcium Intake Is Inversely Related to Risk of Obesity among American Young Adults over a 30-Year Follow-Up.The Journal of nutrition · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectiveTo determine whether intraindividual variability in fasting glucose (FG) below the threshold of diabetes is associated with cognitive function in middle adulthood beyond increasing FG. RESEARCH DESIGN AND
methodsWe studied 3,307 CARDIA (Coronary Artery Risk Development in Young Adults) Study participants (age range 18-30 years and enrolled in 1985-1986) at baseline and calculated two measures of long-term glucose variability: the coefficient of variation about the mean FG (CV-FG) and the absolute difference between successive FG measurements (average real variability [ARV-FG]) before the onset of diabetes over 25 and 30 years of follow-up. Cognitive function was assessed at years 25 (2010-2011) and 30 (2015-2016) with the Digit Symbol Substitution Test (DSST), Rey-Auditory Verbal Learning Test (RAVLT), Stroop Test, Montreal Cognitive Assessment, and category and letter fluency tests. We estimated the association between glucose variability and cognitive function test score with adjustment for clinical and behavioral risk factors, mean FG level, change in FG level, and diabetes development, medication use, and duration.
resultsAfter multivariable adjustment, 1-SD increment of CV-FG was associated with worse cognitive scores at year 25: DSST, standardized regression coefficient -0.95 (95% CI -1.54, -0.36); RAVLT, -0.14 (95% CI -0.27, -0.02); and Stroop Test, 0.49 (95% CI 0.04, 0.94). Findings were similar between CV-FG with each cognitive test score at year 30 and when we used an alternative measure of variability (ARV-FG) that captures variability in successive FG values.
conclusionsHigher intraindividual FG variability during young adulthood below the threshold of diabetes was associated with worse processing speed, memory, and language fluency in midlife independent of FG levels.
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