ArticleJournal of immunology (Baltimore, Md. : 1950)2018
Cutting Edge: IL-1α and Not IL-1β Drives IL-1R1-Dependent Neonatal Murine Sepsis Lethality.
Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Depletion of Neonatal Neutrophilic Cells Worsens the Outcome of E. coli Sepsis in Newborn Mice.European journal of immunology · 2026Article
- Activation of integrin signaling up-regulates pro-inflammatory cytokines in JAK2-V617F positive hematopoietic cells.Cell communication and signaling : CCS · 2025Article
- Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease.Nature communications · 2025Article
- Progress in the application of nanoparticles for the treatment of fungal infections: A review.Mycology · 2024Review
- Argon inhalation attenuates systemic inflammation and rescues lung architecture during experimental neonatal sepsis.Pediatric surgery international · 2023Article
- The Role of the Interleukin-1 Family in Complications of Prematurity.International journal of molecular sciences · 2023Review
- Potent anti-inflammatory responses: Role of hydrogen in IL-1α dominated early phase systemic inflammation.Frontiers in pharmacology · 2023Article
- IL-1β promotes IL-9-producing Th cell differentiation in IL-2-limiting conditions through the inhibition of BCL6.Frontiers in immunology · 2022Article
- Pathogen infection-responsive nanoplatform targeting macrophage endoplasmic reticulum for treating life-threatening systemic infection.Nano research · 2022Article
- Sepsis, Cytokine Storms, and Immunopathology: The Divide between Neonates and Adults.ImmunoHorizons · 2021Article
- An immunopathogenic perspective of interleukin-1 signaling.Cellular & molecular immunology · 2020Article
- Investigation of the IL-1β +3954 C>T polymorphism and the risk of sepsis: A case-control study.Medicine · 2020Article
- Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection.Nature communications · 2020Article
- Cell-specific conditional deletion of interleukin-1 (IL-1) ligands and its receptors: a new toolbox to study the role of IL-1 in health and disease.Journal of molecular medicine (Berlin, Germany) · 2020Review
- IL-1R Regulates Disease Tolerance and Cachexia inJournal of immunology (Baltimore, Md. : 1950) · 2020Article
- BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis.Science translational medicine · 2020Article
- Exploring Clinically-Relevant Experimental Models of Neonatal Shock and Necrotizing Enterocolitis.Shock (Augusta, Ga.) · 2020Review
- CpG-ODN-mediated TLR9 innate immune signalling and calcium dyshomeostasis converge on the NFκB inhibitory protein IκBβ to drive IL1α and IL1β expression.Immunology · 2020Article
- Review
- Whole blood transcriptional responses of very preterm infants during late-onset sepsis.PloS one · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Sepsis disproportionately affects the very old and the very young. IL-1 signaling is important in innate host defense but may also play a deleterious role in acute inflammatory conditions (including sepsis) by promulgating life-threatening inflammation. IL-1 signaling is mediated by two distinct ligands: IL-1α and IL-1β, both acting on a common receptor (IL-1R1). IL-1R1 targeting has not reduced adult human sepsis mortality despite biologic plausibility. Because the specific role of IL-1α or IL-1β in sepsis survival is unknown in any age group and the role of IL-1 signaling remains unknown in neonates, we studied the role of IL-1 signaling, including the impact of IL-1α and IL-1β, on neonatal murine sepsis survival. IL-1 signaling augments the late plasma inflammatory response to sepsis. IL-1α and not IL-1β is the critical mediator of sepsis mortality, likely because of paracrine actions within the tissue. These data do not support targeting IL-1 signaling in neonates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.