Evidence map›Paper›PMID 30305179›Full record

ArticleBreast cancer research : BCR2018

Serially transplantable mammary epithelial cells express the Thy-1 antigen.

Neethan Amit Lobo, Maider Zabala, Dalong Qian, Michael F Clarke

Open access · goldAbstract read
In one paragraph

Article in Breast cancer research : BCR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Neethan Amit LoboInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, 265 Campus Drive, Stanford, CA, 94305, USA.
Maider ZabalaInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, 265 Campus Drive, Stanford, CA, 94305, USA.
Dalong QianInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, 265 Campus Drive, Stanford, CA, 94305, USA.
Michael F ClarkeInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, 265 Campus Drive, Stanford, CA, 94305, USA. mfclarke@stanford.edu.ORCID 0000-0001-6889-4926
Stanford University · USCalifornia Institute for Regenerative Medicine · USUniversity of Michigan · US

Funding

therapeutic Targeting of CD47 on Human Leukemia and Other Cancer Stem CellsP01CA139490 · NCI · STANFORD UNIVERSITY · PI CLARKE, MICHAEL · 2009 to 2013
$8.7M
Self-Renewal of Normal and Leukemic Stem CellsR01CA100225 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CLARKE, MICHAEL · 2004 to 2015
$2.9M
Cellular hierachy of ER- breast cancers in different ethnic groupsU01CA154209 · NCI · STANFORD UNIVERSITY · PI CLARKE, MICHAEL · 2010 to 2014
$2.5M
NCI NIH HHS 5P01 CA139490-05NCI NIH HHS 5R01 CA100225-09NCI NIH HHS 5U01 CA154209-04NCI NIH HHS P01 CA139490NCI NIH HHS R01 CA100225NCI NIH HHS U01 CA154209
6 · The paper itself

Abstract

backgroundRecent studies in murine mammary tissue have identified functionally distinct cell populations that may be isolated by surface phenotype or lineage tracing. Previous groups have shown that CD24

methodsFlow cytometry-based enrichment of distinct phenotypic populations was assessed for their gene expression profiles and functional proliferative attributes in vitro and in vivo.

resultsHere, we show Thy-1 is differentially expressed in the CD24

conclusionsTherefore, Thy-1 expression in the immature cell compartment is a useful tool to study the functional heterogeneity that drives mammary gland development and has implications for disease etiology.

Indexed as

Gene Expression ProfilingAnimalsBreast NeoplasmsCD24 AntigenCell LineageCells, CulturedEpithelial CellsFemaleHumansIntegrin alpha6Mammary Glands, AnimalMice, Inbred C57BLPhenotypeThy-1 AntigensCD24 AntigenIntegrin alpha6Thy-1 AntigensIn vivo serial transplantationProgenitor cellsSelf-renewalTissue-specific stem cells

Identifiers

PMID30305179
PMCPMC6180607
OpenAlexW2897127615

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.