ArticleBiology of sex differences2018
Sex influences the association between haemostasis and the extent of lung lesions in tuberculosis.
Article in Biology of sex differences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Male Sex Is Associated With Worse Microbiological and Clinical Outcomes Following Tuberculosis Treatment: A Retrospective Cohort Study, a Systematic Review of the Literature, and Meta-analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Pooled it
- Article
- Pulmonary tuberculosis mimicking cystic metastases: evolution from multiple cystic cavities to nodules during therapy.BMC infectious diseases · 2026Article
- Sex as a Biological Variable in Tuberculosis Pathogenesis.Immunological reviews · 2026Review
- Pulmonary function impairment patterns and their clinical correlates in patients with pulmonary tuberculosis complicated by pulmonary infection: a single-center retrospective cross-sectional study.Frontiers in medicine · 2026Article
- Assessment of some hematological and inflammatory parameters among patients with active pulmonary tuberculosis in Ibb governorate, Yemen.BMC infectious diseases · 2025Article
- Factors associated with post-treatment resorption of lung cavities in individuals with first episodes of drug-sensitive cavitary pulmonary tuberculosis in China.BMC infectious diseases · 2025Article
- Influence of Type 2 Diabetes Mellitus on the Clinical Outcomes in Hospitalized Patients with Active Pulmonary Tuberculosis: A Retrospective, Single-Center, Real-World Study in China.Infection and drug resistance · 2025Article
- The conneXion between sex and immune responses.Nature reviews. Immunology · 2024Review
- Differential effects of sex on tuberculosis location and severity across the lifespan.Scientific reports · 2023Article
- Sex and Gender Differences in Tuberculosis Pathogenesis and Treatment Outcomes.Current topics in microbiology and immunology · 2023Review
- Sex Differences in Active Pulmonary Tuberculosis Outcomes in Mali, West Africa.The American journal of tropical medicine and hygiene · 2022Article
- Hemostatic parameters in pulmonary tuberculosis patients after intensive phase treatment.Caspian journal of internal medicine · 2021Article
- Sex Disparity in Severity of Lung Lesions in Newly Identified Tuberculosis Is Age-Associated.Frontiers in medicine · 2019Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWorldwide tuberculosis (TB) reports show a male bias in morbidity; however, the differences in pathogenesis between men and women with TB, as well as the mechanisms associated with such differences, are poorly investigated. We hypothesized that comparison of the degree of lung injury and clinical indices of well-matched men and women with newly diagnosed TB, and statistical analysis of the correlation between these indices and the extent of lung lesions, can provide insights into the mechanism of gender bias in TB.
methodsWe evaluated the acid-fast bacilli grading of sputum samples and compiled computed tomography (CT) data of the age-matched, newly diagnosed male and female TB patients without history of smoking or comorbidities. Inflammatory biomarker levels and routine haematological and coagulation-associated parameters were compared. Binary logistic regression analysis was used to define the association between the indices and lung lesions, and the influence of sex adjustment.
resultsWomen with TB have a longer delay in seeking healthcare than men after onset of the TB-associated symptoms. Men with TB have significantly more severe lung lesions (cavities and healing-associated features) and higher bacterial counts compared to women with TB. Scoring of the CT images before and after anti-TB treatment showed a faster response to therapy in women than in men. Coagulation- and platelet-associated indices were in models from multivariate regression analysis with groups of males or females with TB or in combination. In univariate regression analysis, lower lymphocyte counts were associated with both cavity and more bacterial counts, independent of sex, age and BMI. The association of international normalized ratios (INR), prothrombin times (PTs), mean platelet volumes (MPVs) and fibrinogen (FIB) level with lung lesions was mostly influenced by sex adjustment.
conclusionsSex influences the association between haemostasis and extent of TB lung lesions, which may be one mechanism involved in sex bias in TB pathogenesis.
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