Evidence map›Paper›PMID 30305130›Full record

ReviewActa veterinaria Scandinavica2018

Adoptive cell transfer: new perspective treatment in veterinary oncology.

Joanna Katarzyna Bujak, Rafał Pingwara, Michelle Hase Nelson, Kinga Majchrzak

Abstract readReview
In one paragraph

Review in Acta veterinaria Scandinavica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. A New Method of Canine CD4International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Joanna Katarzyna BujakDepartment of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, ul. Nowoursynowska 159, 02-776, Warsaw, Poland.
Rafał PingwaraDepartment of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, ul. Nowoursynowska 159, 02-776, Warsaw, Poland.
Michelle Hase NelsonDepartment of Microbiology and Immunology, Medical University of South Carolina, 86 Jonathan Lucas Street HCC-612, Charleston, SC, 29425, USA.
Kinga MajchrzakDepartment of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, ul. Nowoursynowska 159, 02-776, Warsaw, Poland. kinga_majchrzak@sggw.pl.ORCID http://orcid.org/0000-0002-9504-4588

Funding

Fundacja na rzecz Nauki Polskiej FIRST TEAM 0107Narodowe Centrum Nauki UMO-2016/21/N/NZ6/02137
6 · The paper itself

Abstract

Cancer immunotherapy is recently considered the most promising treatment for human patients with advanced tumors and could be effectively combined with conventional therapies such as chemotherapy or radiotherapy. Patients with hematological malignancies and melanoma have benefited greatly from immunotherapies such as, adoptive cell transfer therapy, experiencing durable remissions and prolonged survival. In the face of increasing enthusiasm for immunotherapy, particularly for the administration of tumor-specific T lymphocytes, the question arises whether this method could be employed to improve treatment outcomes for canine patients. It is warranted to determine whether veterinary clinical trials could support comparative oncology research and thus facilitate the development of new cell-based therapies for humans. Herein, we discuss adoptive transfer of T lymphocytes and lymphokine-activated cells for application in veterinary oncology, in the context of human medicine achievements. Furthermore, we discuss potential benefits of using domestic dog as a model for immunotherapy and its advantages for translational medicine. We also focus on an emerging genome-editing technology as a useful tool to improve a T cells' phenotype.

Indexed as

Disease Models, AnimalAdoptive TransferAnimalsDog DiseasesDogsHumansImmunotherapy, AdoptiveNeoplasmsAdoptive cell transferCanine oncologyGene editingImmunotherapyT lymphocytes

Identifiers

PMID30305130
PMCPMC6180494

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.