Evidence map›Paper›PMID 30304986›Full record

ArticleNeurocase2018

A neuropathologic diagnosis of Alzheimer's disease in an older adult with HIV-associated neurocognitive disorder.

Joanna Hellmuth, Benedetta Milanini, Eliezer Masliah, Maria Carmela Tartaglia, Miranda B Dunlop, David J Moore, Shireen Javandel, Saskia DeVaughn, Victor Valcour

Abstract readCase Reports
In one paragraph

Article in Neurocase, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Alzheimer Dementia in People Living With HIV.Neurology. Clinical practice · 2021
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Treating Alzheimer's disease in a person living with HIV.Alzheimer's & dementia (Amsterdam, Netherlands)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joanna Hellmutha Memory and Aging Center, Department of Neurology , University of California, San Francisco , California, CA , USA.
Benedetta Milaninia Memory and Aging Center, Department of Neurology , University of California, San Francisco , California, CA , USA.
Eliezer Masliahb Departments of Neurosciences and Pathology , University of California, San Diego , California, CA, USA.
Maria Carmela Tartagliac University of Toronto, Tanz Centre for Research in Neurodegenerative Diseases , Toronto , Canada.
Miranda B Dunlopd Department of Internal Medicine , University of California, San Francisco , California, CA, USA.
David J Mooree Department of Psychiatry , University of California, San Diego , California, CA,USA.
Shireen Javandela Memory and Aging Center, Department of Neurology , University of California, San Francisco , California, CA , USA.
Saskia DeVaughna Memory and Aging Center, Department of Neurology , University of California, San Francisco , California, CA , USA.
Victor Valcoura Memory and Aging Center, Department of Neurology , University of California, San Francisco , California, CA , USA.

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello · 2001 to 2026
$50.4M
California NeuroAIDS Tissue NetworkU24MH100928 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ACHIM, CRISTIAN L, MOORE, DAVID J · 2013 to 2023
$13.9M
Machine learning to distinguish HAND from Alzheimer's disease in HIV over age 60R01MH113406 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POHL, KILIAN MARIA, VALCOUR, VICTOR · 2017 to 2021
$5.5M
Neuroimmune responses and therapeutics of alpha-synucleinopathies of the aging populationZIAAG000936 · NIA · NATIONAL INSTITUTE ON AGING · PI COOKSON, MARK · 2017 to 2025
$4.1M
Defining the clinical utility of CSF biomarkers of neurodegeneration in HIV+ eldersK23MH114724 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HELLMUTH, JOANNA · 2017 to 2020
$796k
NIMH NIH HHS K23 MH114724NIMH NIH HHS P30 MH062512NIMH NIH HHS R01 MH113406NIMH NIH HHS U24 MH100928
6 · The paper itself

Abstract

We discuss the challenges associated with diagnosing neurodegenerative disorders in older adults living with HIV, illustrated through a case report where neurologic co-diagnosis of Alzheimer's disease (AD) and HIV-associated Neurocognitive Disorder (HAND) are considered. The patient was followed and evaluated for over 4 years and underwent post-mortem neuropathologic evaluation. Further work is needed to identify diagnostic tests that can adequately distinguish HAND from early stage neurodegenerative disorders among older adults living with HIV and cognitive changes.

Indexed as

Aged, 80 and overAIDS Dementia ComplexAlzheimer DiseaseBrainHumansMagnetic Resonance ImagingMaleNeuropsychological TestsAlzheimer’s diseasedementiaHIV-associated neurocognitive disorderneuropathologyneuropsychological testing

Identifiers

PMID30304986
PMCPMC6226354

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.