Evidence map›Paper›PMID 30304824›Full record

ReviewInternational journal of molecular sciences2018

Neuronal Cell Death Mechanisms in Major Neurodegenerative Diseases.

Hao Chi, Hui-Yun Chang, Tzu-Kang Sang

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 217 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
217citing papers in PubMed, 5 pooled it
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

217 citing papers in PubMed, 5 syntheses or guidelines pooled it, 394 citations in OpenAlex.

  1. Pooled it
  2. Nutrients · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Review
  8. Metallothionein and neurodegenerative diseases.Neural regeneration research · 2026
    Article
  9. Article
  10. Review
  11. TREM2 in neurodegeneration and diseases.Molecular psychiatry · 2026
    Review
  12. Necroptosis in Down Syndrome.Cell death & disease · 2026
    Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Icariin Against Neurodegeneration: A Focus in Cell Death Pathways.International journal of molecular sciences · 2026
    Review

157 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hao ChiInstitute of Biotechnology, National Tsing Hua University, Hsinchu City 30013, Taiwan. s105080871@m105.nthu.edu.tw.
Hui-Yun ChangInstitute of Systems Neuroscience, National Tsing Hua University, Hsinchu City 30013, Taiwan. huiyun@life.nthu.edu.tw.
Tzu-Kang SangInstitute of Biotechnology, National Tsing Hua University, Hsinchu City 30013, Taiwan. tksang@life.nthu.edu.tw.
National Tsing Hua University · TW

Funding

Ministry of Science and Technology, Taiwan 106-2311-B-007-008-MY3Ministry of Science and Technology, Taiwan 107-2311-B-007-006
6 · The paper itself

Abstract

Neuronal cell death in the central nervous system has always been a challenging process to decipher. In normal physiological conditions, neuronal cell death is restricted in the adult brain, even in aged individuals. However, in the pathological conditions of various neurodegenerative diseases, cell death and shrinkage in a specific region of the brain represent a fundamental pathological feature across different neurodegenerative diseases. In this review, we will briefly go through the general pathways of cell death and describe evidence for cell death in the context of individual common neurodegenerative diseases, discussing our current understanding of cell death by connecting with renowned pathogenic proteins, including Tau, amyloid-beta, alpha-synuclein, huntingtin and TDP-43.

Indexed as

Cell DeathAnimalsApoptosisBrainHumansNeurodegenerative DiseasesNeuronsapoptosisnecroptosisneurodegeneration

Identifiers

PMID30304824
PMCPMC6213751
OpenAlexW2897537084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.