Evidence map›Paper›PMID 30304689›Full record

ArticleCell reports2018

The 10,000 Immunomes Project: Building a Resource for Human Immunology.

Kelly A Zalocusky, Matthew J Kan, Zicheng Hu, Patrick Dunn, Elizabeth Thomson, Jeffrey Wiser, Sanchita Bhattacharya, Atul J Butte

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Translational cancer research · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. ZNF91 is an endogenous repressor of the molecular phenotype associated with X-linked dystonia-parkinsonism (XDP).Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. The "Virtual Digital Twins" Concept in Precision Nutrition.Advances in nutrition (Bethesda, Md.) · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Kelly A ZalocuskyBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94158, USA.
Matthew J KanBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94158, USA.
Zicheng HuBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94158, USA.
Patrick DunnInformation Systems Health IT, Northrop Grumman, Rockville, MD 20850, USA.
Elizabeth ThomsonInformation Systems Health IT, Northrop Grumman, Rockville, MD 20850, USA.
Jeffrey WiserInformation Systems Health IT, Northrop Grumman, Rockville, MD 20850, USA.
Sanchita BhattacharyaBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94158, USA.
Atul J ButteBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: atul.butte@ucsf.edu.

Funding

NIAID NIH HHS HHSN272201200028C
6 · The paper itself

Abstract

There is increasing appreciation that the immune system plays critical roles not only in the traditional domains of infection and inflammation but also in many areas of biology, including tumorigenesis, metabolism, and even neurobiology. However, one of the major barriers for understanding human immunological mechanisms is that immune assays have not been reproducibly characterized for a sufficiently large and diverse healthy human cohort. Here, we present the 10,000 Immunomes Project (10KIP), a framework for growing a diverse human immunology reference, from ImmPort, a publicly available resource of subject-level immunology data. Although some measurement types are sparse in the presently deposited ImmPort database, the extant data allow for a diversity of robust comparisons. Using 10KIP, we describe variations in serum cytokines and leukocytes by age, race, and sex; define a baseline cell-cytokine network; and describe immunologic changes in pregnancy. All data in the resource are available for visualization and download at http://10kimmunomes.org/.

Indexed as

Databases, FactualAdolescentAdultBiomarkersCohort StudiesComputational BiologyCytokinesFemaleGene Regulatory NetworksHumansImmune SystemLeukocytesMalePregnancyYoung AdultBiomarkersCytokines

Identifiers

PMID30304689
PMCPMC6263160

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.