ArticleCell reports2018
Microtubule-Actomyosin Mechanical Cooperation during Contact Guidance Sensing.
Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- Biomimetic hydrogel for the construction of patient-derived bladder cancer organoids with aggressive growth.iScience · 2026Article
- Formins and Arp2/3 Reciprocally Regulate Contact Guidance on Aligned Collagen Fibrils.Cellular and molecular bioengineering · 2025Article
- Nano- and Microscale Chemical and Topographical Patterning of Synthetic Cell Scaffolds: from Hard to Soft Materials.ACS materials Au · 2025Review
- Extracellular matrix architecture promotes immunosuppressive microenvironments in pancreatic cancer.Matrix biology : journal of the International Society for Matrix Biology · 2025Article
- Aligned Collagen Fibers Drive Distinct Traction Force Signatures to Regulate Contact Guidance.ACS nano · 2025Article
- Microtubules and mechanosensing: key players in endothelial responses to mechanical stimuli.Cellular and molecular life sciences : CMLS · 2025Review
- Analysis of 2-dimensional regional differences in the peripapillary scleral fibroblast cytoskeleton of normotensive and hypertensive mouse eyes.Scientific reports · 2025Article
- Microtubules Disruption Alters the Cellular Structures and Mechanics Depending on Underlying Chemical Cues.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- A multimodal microfluidic-based platform integrating topographical and equibiaxial mechanical cues for next-generationFrontiers in bioengineering and biotechnology · 2025Article
- Microtopography-Induced Nuclear Deformation Triggers Chromatin Reorganization and Cytoskeleton Remodeling.Chemical & biomedical imaging · 2024Article
- Thermosensory Spiking Activity of Proteinoid Microspheres Cross-Linked by Actin Filaments.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Effect of Anisotropic Structural Depth on Orientation and Differentiation Behavior of Skeletal Muscle Cells.ACS omega · 2023Article
- Dynein-Powered Cell Locomotion Guides Metastasis of Breast Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- A noncommutative combinatorial protein logic circuit controls cell orientation in nanoenvironments.Science advances · 2023Article
- Dynein-Powered Cell Locomotion Guides Metastasis of Breast Cancer.bioRxiv : the preprint server for biology · 2023Article
- Soft topographical patterns trigger a stiffness-dependent cellular response to contact guidance.Materials today. Bio · 2023Article
- Nanotopography modulates cytoskeletal organization and dynamics during T cell activation.Molecular biology of the cell · 2022Article
- Stromal architecture directs early dissemination in pancreatic ductal adenocarcinoma.JCI insight · 2022Article
- Characterization of Integrin Molecular Tension of Human Breast Cancer Cells on Anisotropic Nanopatterns.Frontiers in molecular biosciences · 2022Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Cancer cell migration through and away from tumors is driven in part by migration along aligned extracellular matrix, a process known as contact guidance (CG). To concurrently study the influence of architectural and mechanical regulators of CG sensing, we developed a set of CG platforms. Using flat and nanotextured substrates with variable architectures and stiffness, we show that CG sensing is regulated by substrate stiffness and define a mechanical role for microtubules and actomyosin-microtubule interactions during CG sensing. Furthermore, we show that Arp2/3-dependent lamellipodia dynamics can compete with aligned protrusions to diminish the CG response and define Arp2/3- and Formins-dependent actin architectures that regulate microtubule-dependent protrusions, which promote the CG response. Thus, our work represents a comprehensive examination of the physical mechanisms influencing CG sensing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.