ArticleSchizophrenia bulletin2019
Transcranial Direct Current Stimulation Improves Semantic Speech-Gesture Matching in Patients With Schizophrenia Spectrum Disorder.
Article in Schizophrenia bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Gesture deficits in psychosis and the combination of group psychotherapy and transcranial magnetic stimulation: A randomized clinical trial.Molecular psychiatry · 2025Trial
- Single Session Transcranial Magnetic Stimulation Ameliorates Hand Gesture Deficits in Schizophrenia.Schizophrenia bulletin · 2020Trial
- Speech-Gesture Matching and Schizotypal Traits: A Network Approach.Schizophrenia bulletin · 2025Article
- A Developmental Perspective on Early and Current Motor Abnormalities and Psychotic-Like Symptoms.Schizophrenia bulletin · 2025Article
- A pilot study to investigate the efficacy and tolerability of lesion network guided transcranial electrical stimulation in outpatients with psychosis spectrum illness.Asian journal of psychiatry · 2023Article
- The Processing of Semantic Complexity and Cospeech Gestures in Schizophrenia: A Naturalistic, Multimodal fMRI Study.Schizophrenia bulletin open · 2022Article
- Neural Basis of Speech-Gesture Mismatch Detection in Schizophrenia Spectrum Disorders.Schizophrenia bulletin · 2021Article
- Abnormal Gesture Perception and Clinical High-Risk for Psychosis.Schizophrenia bulletin · 2021Article
- The Role of Iconic Gestures in Speech Comprehension: An Overview of Various Methodologies.Frontiers in psychology · 2021Review
- Nonverbal communication remains untouched: No beneficial effect of symptomatic improvement on poor gesture performance in schizophrenia.Schizophrenia research · 2020Article
- A Multimodal Speech-Gesture Training Intervention for Patients With Schizophrenia and Its Neural Underpinnings - the Study Protocol of a Randomized Controlled Pilot Trial.Frontiers in psychiatry · 2020Article
- Transcranial direct current stimulation improves action-outcome monitoring in schizophrenia spectrum disorder.Brain communications · 2020Article
- As Motor System Pathophysiology Returns to the Forefront of Psychosis Research, Clinical Implications Should Hold Center Stage.Schizophrenia bulletin · 2019Article
- Role of Sensorimotor Cortex in Gestural-Verbal Integration.Frontiers in human neuroscience · 2018Article
- Improving causality perception judgments in schizophrenia spectrum disorder via transcranial direct current stimulation.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with schizophrenia spectrum disorders (SSD) have severe deficits in speech and gesture processing that contribute considerably to the burden of this disorder. Brain imaging shows left inferior frontal gyrus involvement for impaired processing of co-verbal gestures in patients with schizophrenia. Recently, transcranial direct current stimulation (tDCS) of the left frontal lobe has been shown to modulate processing of co-verbal gestures in healthy subjects. Although tDCS has been used to reduce symptoms of patients with SSD, the effects of tDCS on gesture processing deficits remain hitherto unexplored.
objectiveHere we tested the hypothesis that inhibitory cathodal tDCS of the left frontal lobe decreases pathological dysfunction and improves semantic processing of co-verbal gestures in patients with SSD.
methodsWe measured ratings and reaction times in a speech-gesture semantic relatedness assessment task during application of frontal, frontoparietal, parietal, and sham tDCS to 20 patients with SSD and 29 healthy controls.
resultsWe found a specific effect of tDCS on speech-gesture relatedness ratings of patients. Frontal compared to parietal and sham stimulation significantly improved the differentiation between related and unrelated gestures. Placement of the second electrode (right frontal vs parietal) did not affect the effect of left frontal stimulation, which reduced the preexisting difference between patients and healthy controls.
conclusionHere we show that left frontal tDCS can improve semantic co-verbal gesture processing in patients with SSD. tDCS could be a viable tool to normalize processing in the left frontal lobe and facilitate direct social communicative functioning in patients with SSD.
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