SynthesisDental press journal of orthodontics2018
Side effects of mandibular advancement splints for the treatment of snoring and obstructive sleep apnea: a systematic review.
Synthesis in Dental press journal of orthodontics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Comparison of side effects of different mandibular advancement devices for patients with obstructive sleep apnea: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Pooled it
- Effect of mandibular advancement appliance use on oral and periodontal health in patients with OSA: a systematic review.Sleep & breathing = Schlaf & Atmung · 2024Pooled it
- Oral appliance-generated malocclusion traits during the long-term management of obstructive sleep apnea in adults.The Angle orthodontist · 2022Pooled it
- Ultrasonographic evaluation of masticatory and suprahyoid muscles in obstructive sleep apnea patients treated with mandibular advancement devices; a pilot study.Head & face medicine · 2025Trial
- 3-D changes in tooth position after treatment with mandibular advancement devices -a retrospective study in a non-university setting.BMC oral health · 2025Article
- Clinical Efficacy of a Position-Responding Mandibular Advancement Device in Patients With Obstructive Sleep Apnea.Clinical and experimental otorhinolaryngology · 2024Article
- Sleep and periodontal health.Periodontology 2000 · 2024Review
- Automatic prediction of obstructive sleep apnea in patients with temporomandibular disorder based on multidata and machine learning.Scientific reports · 2024Article
- Objectively measured adherence may affect side effects of mandibular advancement therapy in subjects with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2024Article
- Indications for Dental Specialists for Treating Obstructive Sleep Apnea with Mandibular Advancement Devices: A Narrative Review.International journal of dentistry · 2024Review
- Mandibular advancement devices used with morning occlusal guides for treating obstructive sleep apnea-changed incisor inclination and its associated factors.Sleep & breathing = Schlaf & Atmung · 2023Article
- Dental and Skeletal Side Effects of Oral Appliances Used for the Treatment of Obstructive Sleep Apnea and Snoring in Adult Patients-A Systematic Review and Meta-Analysis.Journal of personalized medicine · 2022Review
- Obstructive sleep apnoea/hypopnoea syndrome: relationship with obesity and management in obese patients.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2021Review
- A consideration of factors affecting palliative oral appliance effectiveness for obstructive sleep apnea: a scoping review.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- Clinical and Research Solutions to Manage Obstructive Sleep Apnea: A Review.Sensors (Basel, Switzerland) · 2021Review
- Semi-fixed versus fixed oral appliance therapy for obstructive sleep apnea: A randomized crossover pilot study.Journal of dental sciences · 2021Article
- Review of systematic reviews on mandibular advancement oral appliance for obstructive sleep apnea: The importance of long-term follow-up.The Japanese dental science review · 2020Review
- How much is too much after all? Primary snoring as a remaining unsolved issue.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Different approaches to the treatment of skeletal Class II malocclusion during growth: Bionator versus extraoral appliance.Dental press journal of orthodontics · 2020Article
- Obstructive sleep apnea in adults.Dental press journal of orthodontics · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionOcclusal side effects or development of pain and/or functional impairment of the temporomandibular complex are potential reasons for poor compliance or abandonment of mandibular advancement splints treatment for snoring and obstructive sleep apnea.
objectiveThis study aimed at providing a comprehensive review evaluating the craniofacial side effects of oral appliance therapy for snoring and obstructive sleep apnea.
methodsAn electronic search was systematically conducted in PubMed and Virtual Health Library from their inception until October 2016. Only Randomized Controlled Trials whose primary aim was to measure objectively identified side effects on craniofacial complex of a custom-made oral appliance for treating primary snoring or obstructive sleep apnea were included. Studied patients should be aged 20 or older. The risk of bias in the trials was assessed in accordance with the recommendations of The Cochrane Risk of Bias criteria.
resultsA total of 62 full-text articles were assessed for eligibility. After the review process, only 6 met all the inclusion criteria. All studies were rated as having a high risk of bias. The most uniformly reported mandibular advancement splint side effects were predominantly of dental nature and included a decrease in overjet and overbite. The risk of developing pain and function impairment of the temporomandibular complex appeared limited with long-term mandibular advancement splint use.
conclusionThe limited available evidence suggests that mandibular advancement splint therapy for snoring and obstructive sleep apnea results in changes in craniofacial morphology that are predominantly dental in nature, specially on a long-term basis. Considering the chronic nature of obstructive sleep apnea and that oral appliance use might be a lifelong treatment, a thorough customized follow-up should therefore be undertaken to detect possible side effects on craniofacial complex. It is also important to provide adequate information to the patients regarding these possible changes, especially to those in whom larger occlusal changes are to be expected or in whom they are unfavorable. Long-term assessments of adverse effects of oral appliance therapy, with larger study samples and recruitment of homogenous patient population are still required.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.