Evidence map›Paper›PMID 30304114›Full record

ArticleArchives of endocrinology and metabolism2018

The low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism: candidate for susceptibility to type 1 diabetes mellitus.

Karla Simone Costa de Souza, Marcela Abbott Galvão Ururahy, Yonara Monique da Costa Oliveira, Melina Bezerra Loureiro, Heglayne Pereira Vital da Silva, Raul Hernandes Bortolin, André Ducati Luchessi, Ricardo Fernando Arrais, Rosário Dominguez Crespo Hirata, Maria das Graças Almeida and 2 more

Open access · diamondAbstract read
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In one paragraph

Article in Archives of endocrinology and metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Karla Simone Costa de SouzaDepartamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brasil.
Marcela Abbott Galvão UrurahyDepartamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brasil.
Yonara Monique da Costa OliveiraDepartamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brasil.
Melina Bezerra LoureiroDepartamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brasil.
Heglayne Pereira Vital da SilvaDepartamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brasil.
Raul Hernandes BortolinDepartamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brasil.
André Ducati LuchessiDepartamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brasil.
Ricardo Fernando ArraisDepartamento de Pediatria, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brasil.
Rosário Dominguez Crespo HirataDepartamento de Análises Clínicas e Toxicológicas, Universidade de São Paulo (USP), São Paulo, SP, Brasil.
Maria das Graças AlmeidaDepartamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brasil.
Mário Hiroyuki HirataDepartamento de Análises Clínicas e Toxicológicas, Universidade de São Paulo (USP), São Paulo, SP, Brasil.
Adriana Augusto de RezendeDepartamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brasil.
Universidade Federal do Rio Grande do Norte · BRUniversidade de São Paulo · BRUniversidade Federal de Campina Grande · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe present study has investigated the association between low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism and type 1 diabetes mellitus (T1DM) susceptibility in a Brazilian population. SUBJECTS AND

methodsA total number of 134 T1DM patients and 180 normoglycemic individuals (NG) aged 6-20 years were studied. Glycated hemoglobin and glucose levels were determined. Genotyping of LRP5 4037C>T (rs3736228) was performed.

resultsT1DM patients showed poor glycemic control. Genotypes in the codominant (CT: OR = 2.99 [CI 95%: 1.71-5.24], p < 0.001; TT: OR = 5.34 [CI 95%: 1.05-2702], p < 0.001), dominant (CT + TT: OR = 3.16 [CI 95%: 1.84-5.43], p < 0.001) and log-additive (OR = 2.78 [CI 95%: 1.70-4.52], p < 0.001) models, and LRP5 4037T allele (OR = 2.88, [CI 95%: 1.78-4.77], p < 0.001) were associated with an increased risk of developing T1DM. LRP5 4037CT and CT+TT carriers in T1DM group showed higher concentrations of serum glucose and glycated hemoglobin when compared with CC carriers.

conclusionThe LRP5 4037C>T may represent a candidate for T1DM susceptibility, as well as poor glycemic control.

Indexed as

AdolescentBlood GlucoseBrazilChildDiabetes Mellitus, Type 1FemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeGlycated HemoglobinHumansLow Density Lipoprotein Receptor-Related Protein-5MalePolymorphism, GeneticBlood GlucoseGlycated HemoglobinLow Density Lipoprotein Receptor-Related Protein-5LRP5 protein, human

Identifiers

PMID30304114
PMCPMC10118729
OpenAlexW2911841220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.