ArticleArchives of endocrinology and metabolism2018
Low serum 25-hydroxy vitamin D levels are associated with aggressive breast cancer variants and poor prognostic factors in patients with breast carcinoma.
Article in Archives of endocrinology and metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Serum 25-hydroxyvitamin D levels among women newly diagnosed with breast cancer at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia.BMC women's health · 2026Article
- Impact of vitamin D deficiency on disease outcomes in patients with oral squamous cell carcinoma: a retrospective cohort study.Irish journal of medical science · 2026Article
- Effects of Statins on All-Cause Mortality in Patients with Breast Cancer: A Population-Based Study.Biomedicines · 2025Article
- PREVALENCE OF 25-HYDROXYCHOLECALCIFEROL DEFICIENCY AND METABOLIC SYNDROME IN CROATIAN WOMEN WITH NEWLY DIAGNOSED BREAST CANCER.Acta clinica Croatica · 2025Observational
- Bone health in newly diagnosed female breast cancer patients in China: a cross-sectional study.Scientific reports · 2025Article
- Association Between Vitamin D Deficiency and Tumor Characteristics in Breast Cancer Patients.Cureus · 2024Article
- The Impact of Vitamin D and Its Dietary Supplementation in Breast Cancer Prevention: An Integrative Review.Nutrients · 2024Review
- Dual effect of vitamin DBMC cancer · 2024Article
- Evaluation of the relationship between vitamin D levels with oocyte quality in breast cancer women: a cross-sectional study.Scientific reports · 2023Article
- FokI polymorphism of Vitamin D receptor gene and deficiency of serum Vitamin D increases the risk of breast cancer in North Indian women.Endocrine · 2023Article
- The role of vitamin D in menopausal women's health.Frontiers in physiology · 2023Review
- The Association of Intra-Tumoral and Stromal Vitamin D Receptor (VDR) Expressions with Molecular Subtypes and Clinicopathological Factors in Breast Carcinoma.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Effect of Selected Factors on the Serum 25(OH)D Concentration in Women Treated for Breast Cancer.Nutrients · 2021Article
- Lower levels of vitamin D are associated with SARS-CoV-2 infection and mortality in the Indian population: An observational study.International immunopharmacology · 2020Observational
- Association between pre-chemotherapy serum levels of vitamin D and clinicopathologic findings in gastric cancer.Caspian journal of internal medicine · 2020Article
- A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan.PloS one · 2020Article
- Association between serum 25-hydroxy vitamin D level and gastric adenocarcinoma - a cross sectional study.Przeglad gastroenterologicznyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study was conducted to assess the serum 25-hydroxy (OH) vitamin D levels in patients with breast cancer compared to healthy controls and to identify its association with aggressive breast cancer phenotypes. MATERIALS AND
methodsSerum 25-OH vitamin D levels of 78 breast cancer patients and 78 matched healthy controls were estimated using ELISA. The cases and controls were matched with respect to age, menopausal status, parity, weight, height and co-morbidities. Prognostic factors like grade of tumour, hormone receptor status, HER2 neu status and lymphovascular invasion were compared with 25-OH vitamin D levels.
resultsThe mean serum 25-OH vitamin D levels of cases were significantly lower compared to the controls (22.33 ± 8.19 vs. 37.41 ± 12.9 ng/mL; p = 0.0001). Patients with higher grades of tumour, non-luminal types of breast cancer and breast cancers with estrogen receptor negativity had significantly lower serum 25-OH vitamin D levels than their opposing groups. Patients with excellent and good Nottingham's prognostic Index (NPI) had significantly higher serum 25-OH vitamin D levels than the moderate and poor NPI groups.
conclusionNewly diagnosed breast cancer patients have significantly lower serum 25-OH vitamin D levels than healthy controls. Lower level of serum 25-OH vitamin D correlates with aggressive breast cancer phenotypes.
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