ArticlePloS one2018
Characterization of gene expression changes over healthy term pregnancies.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Revealing the Complexity of Immunobiological Shifts From Non-Pregnant to Pregnant State.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Article
- Transcriptomic comparison of early onset preeclampsia and placenta accreta identifies inverse trophoblast and decidua functions at the maternal-fetal interface.npj women's health · 2025Article
- Differential gene expression in two consecutive pregnancies between same sex siblings and implications on maternal constraint.Scientific reports · 2024Article
- Considerations for reproducible omics in aging research.Nature aging · 2023Review
- Pregnancy-associated systemic gene expression compared to a pre-pregnancy baseline, among healthy women with term pregnancies.Frontiers in immunology · 2023Article
- Alterations in Immune-Related Defensin Alpha 4 (International journal of inflammation · 2022Review
- Immune cell type and DNA methylation vary with reproductive status in women: possible pathways for costs of reproduction.Evolution, medicine, and public health · 2022Article
- Regulation of uterine genes during the peri-implantation period, and its relationship to the maternal brain in gestating mice.Molecular reproduction and development · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
During pregnancy, women experience numerous physiological changes but, to date, there is limited published data that characterize accompanying changes in gene expression over pregnancy. This study sought to characterize the complexity of the transcriptome over the course of pregnancy among women with healthy pregnancies. Subjects provided a venous blood sample during early (6-15 weeks) and late (22-33 weeks) pregnancy, which was used to isolate peripheral blood mononuclear cells prior to RNA extraction. Gene expression was examined for 63 women with uncomplicated, term deliveries. We evaluated the association between weeks gestation at sample collection and expression of each transcript. Of the 16,311 transcripts evaluated, 439 changed over pregnancy after a Bonferroni correction to account for multiple comparisons. Genes whose expression increased over pregnancy were associated with oxygen transport, the immune system, and host response to bacteria. Characterization of changes in the transcriptome over the course of healthy term pregnancies may enable the identification of genes whose expression predicts complications or adverse outcomes of pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.