ArticleDiseases of the colon and rectum2018
What Is the Risk of Anal Carcinoma in Patients With Anal Intraepithelial Neoplasia III?
Article in Diseases of the colon and rectum, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Comparing and contrasting clinical consensus and guidelines for anal intraepithelial neoplasia in different geographical regions.Updates in surgery · 2021Pooled it
- Treatment of Anal High-Grade Squamous Intraepithelial Lesions to Prevent Anal Cancer.The New England journal of medicine · 2022Trial
- Anal High-Grade Squamous Intraepithelial Lesions in People Living with HIV: A Systematic Review of Treatment Outcomes.Cancers · 2026Review
- Incidence and burden of anal cancer-time to fight the growing disparities.ESMO gastrointestinal oncology · 2026Review
- Anal Squamous Intraepithelial Lesions: A Primer for Gastroenterologists.Current gastroenterology reports · 2025Review
- Evaluation of Anal Cancer Screening Practices Among a National Cohort of Veterans With HIV.Diseases of the colon and rectum · 2025Article
- Radiation therapy in anal high-grade squamous intraepithelial lesions-a pattern of care analysis in German-speaking countries.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025Article
- Sexually transmitted human papillomavirus and related sequelae.Clinical microbiology reviews · 2025Review
- High-grade intraepithelial lesions of the anus-patience: A road to wisdom.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Article
- Severe anal intraepithelial neoplasia trends and subsequent invasive anal cancer in the United States.Journal of the National Cancer Institute · 2024Article
- Article
- Duration of Time CD4/CD8 Ratio is Below 0.5 is Associated with Progression to Anal Cancer in Patients with HIV and High-Grade Dysplasia.Annals of surgical oncology · 2023Article
- High Grade Anal Dysplasia in People Living with HIV: A Review of the Anal Cancer/HSIL Outcomes Research (ANCHOR) Trial. Implications for Screening and Treatment Strategies to Minimize Anal Cancer in a Very High-risk Population.International journal of cancer care and delivery · 2023Article
- Anal Cancer in High-Risk Women: The Lost Tribe.Cancers · 2022Review
- A nationwide longitudinal study on risk factors for progression of anal intraepithelial neoplasia grade 3 to anal cancer.International journal of cancer · 2022Article
- Identifying anal and cervical tumorigenesis-associated methylation signaling with machine learning methods.Frontiers in oncology · 2022Article
- Local excision and treatment of early node-negative anal squamous cell carcinomas in a highly HIV prevalent population.Techniques in coloproctology · 2021Article
- Cancer Risk Stratification of Anal Intraepithelial Neoplasia in Human Immunodeficiency Virus-Positive Men by Validated Methylation Markers Associated With Progression to Cancer.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Anal squamous cell carcinoma in a high HIV prevalence population.Discover oncology · 2021Article
- Opportunistic detection of anal intraepithelial neoplasia at colonoscopy.JGH open : an open access journal of gastroenterology and hepatology · 2020Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe risk of anal carcinoma after previous diagnosis of anal intraepithelial neoplasia III is unclear.
objectiveThe purpose of this study was to estimate the risk of anal carcinoma in patients with anal intraepithelial neoplasia III and to identify predictors for subsequent malignancy.
designThis was a retrospective review using the Surveillance, Epidemiology, and End Results registry (1973-2014).
settingThe study was composed of population-based cancer registries from the United States. PATIENTS: Patients who were diagnosed with anal intraepithelial neoplasia III were included.
main outcome measuresThe primary outcome was rate of subsequent anal squamous cell carcinoma. Predictors for anal cancer were identified using logistic regression and Cox proportional hazard models.
resultsA total of 2074 patients with anal intraepithelial neoplasia III were identified and followed for a median time of 4.0 years (interquartile range, 1.8-6.7 y). Of the cohort, 171 patients (8.2%) subsequently developed anal cancer. Median time from anal intraepithelial neoplasia III diagnosis to anal cancer diagnosis was 2.7 years (interquartile range, 1.1-4.5 y). Fifty-two patients (30.4%) who developed anal carcinoma were staged T2 or higher. Ablative therapies for initial anal intraepithelial neoplasia III were associated with a reduction in the risk of anal cancer (OR = 0.3 (95% CI, 0.1-0.7); p = 0.004). Time-to-event analysis revealed that the 5-year incidence of anal carcinoma after anal intraepithelial neoplasia III was 9.5% or ≈1.9% per year. LIMITATIONS: The registry did not record HIV status, surveillance schedule, use of high-resolution anoscopy, or provider specialty.
conclusionsIn the largest published cohort of patients with anal intraepithelial neoplasia III, ≈10% of patients were projected to develop anal cancer within 5 years. Nearly one third of anal cancers were diagnosed at stage T2 or higher despite a previous diagnosis of anal intraepithelial neoplasia III. Ablative procedures were associated with a decreased risk of cancer. This study highlights the considerable rate of malignancy in patients with anal intraepithelial neoplasia III and the need for effective therapies and surveillance. See Video Abstract at http://links.lww.com/DCR/A764.
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