Evidence map›Paper›PMID 30303741›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Endothelin receptor A and p66Shc regulate spontaneous Ca

Oleg Palygin, Bradley S Miller, Yoshinori Nishijima, David X Zhang, Alexander Staruschenko, Andrey Sorokin

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Oleg PalyginDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Bradley S MillerCardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Yoshinori NishijimaCardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
David X ZhangCardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Alexander StaruschenkoDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Andrey SorokinCardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Medical College of Wisconsin · US

Funding

Therapeutic Effects of mTOR Inhibition in Salt-Sensitive HypertensionP01HL116264 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI MATTSON, DAVID L. · 2013 to 2021
$18.7M
TRP Channels In The Regulation of Vascular ToneR01HL096647 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI ZHANG, DAVID X. · 2011 to 2024
$5.5M
Renal ion channels in the control of blood pressureR35HL135749 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI STARUSCHENKO, ALEXANDER · 2017 to 2023
$3.6M
Endothelin Signaling and Actions in Renal MesangiumR01DK098159 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI SOROKIN, ANDREY · 2013 to 2016
$1.3M
NHLBI NIH HHS P01 HL116264NHLBI NIH HHS R01 HL096647NHLBI NIH HHS R35 HL135749NIDDK NIH HHS R01 DK098159
6 · The paper itself

Abstract

Adaptor protein p66Shc is overexpressed in smooth muscle cells of renal resistance vessels of hypertensive salt-sensitive rats and is involved in the regulation of renal vascular tone. We applied 2-photon laser scanning fluorescence microscopy to analyze spontaneous dynamic fluctuations in intracellular calcium concentrations ([Ca

Indexed as

Vascular ResistanceAnimalsCalciumCells, CulturedEndothelin-1HypertensionMaleMuscle, Smooth, VascularRatsRats, Inbred DahlReceptor, Endothelin ARenal ArterySrc Homology 2 Domain-Containing, Transforming Protein 1CalciumEndothelin-1Receptor, Endothelin AShc1 protein, ratSrc Homology 2 Domain-Containing, Transforming Protein 1calciumcell signalingendotheliumET-1vascular tonevasomotion

Identifiers

PMID30303741
PMCPMC6338658
OpenAlexW2897671151

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.