Evidence map›Paper›PMID 30303707›Full record

Trial reportAmerican journal of physiology. Regulatory, integrative and comparative physiology2018

The effect of a short-term low-carbohydrate, high-fat diet with or without postmeal walks on glycemic control and inflammation in type 2 diabetes: a randomized trial.

Étienne Myette-Côté, Cody Durrer, Helena Neudorf, Tyler D Bammert, José Diego Botezelli, James D Johnson, Christopher A DeSouza, Jonathan P Little

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of physiology. Regulatory, integrative and comparative physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 7 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 7 syntheses or guidelines pooled it, 92 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Étienne Myette-CôtéSchool of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada.
Cody DurrerSchool of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada.
Helena NeudorfSchool of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada.
Tyler D BammertIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado , Boulder, Colorado.
José Diego BotezelliDepartment of Cellular and Physiological Sciences, University of British Columbia , Vancouver, BC , Canada.
James D JohnsonDepartment of Cellular and Physiological Sciences, University of British Columbia , Vancouver, BC , Canada.
Christopher A DeSouzaIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado , Boulder, Colorado.
Jonathan P LittleSchool of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada.
University of British Columbia · CAUniversity of Colorado Boulder · US

Funding

Sleep and Blood Pressure-Related Endothelial AbnormalitiesR01HL135598 · NHLBI · UNIVERSITY OF COLORADO · PI DESOUZA, CHRISTOPHER A, STAUFFER, BRIAN L · 2017 to 2020
$3.0M
CIHR MSH-141980EPA EP-D-15-016NHLBI NIH HHS R01 HL135598
6 · The paper itself

Abstract

Lowering carbohydrate consumption effectively lowers glucose, but impacts on inflammation are unclear. The objectives of this study were to: 1) determine whether reducing hyperglycemia by following a low-carbohydrate, high-fat (LC) diet could lower markers of innate immune cell activation in type 2 diabetes (T2D) and 2) examine if the combination of an LC diet with strategically timed postmeal walking was superior to an LC diet alone. Participants with T2D ( n = 11) completed a randomized crossover study involving three 4-day diet interventions: 1) low-fat low-glycemic index (GL), 2) and 3) LC with 15-min postmeal walks (LC+Ex). Four-day mean glucose was significantly lower in the LC+Ex group as compared with LC (-5%, P < 0.05), whereas both LC+Ex (-16%, P < 0.001) and LC (-12%, P < 0.001) conditions were lower than GL. A significant main effect of time was observed for peripheral blood mononuclear cells phosphorylated c-Jun N-terminal kinase ( P < 0.001), with decreases in all three conditions (GL: -32%, LC: -45%, and LC+Ex: -44%). A significant condition by time interaction was observed for monocyte microparticles ( P = 0.040) with a significant decrease in GL (-76%, P = 0.035) and a tendency for a reduction in LC (-70%, P = 0.064), whereas there was no significant change in LC+Ex (0.5%, P = 0.990). Both LC (-27%, P = 0.001) and LC+Ex (-35%, P = 0.005) also led to significant reductions in circulating proinsulin. An LC diet improved 4-day glycemic control and fasting proinsulin levels when compared with GL, with added glucose-lowering benefits when LC was combined with postmeal walking.

Indexed as

WalkingAdultAgedBlood GlucoseDiabetes Mellitus, Type 2Dietary CarbohydratesDiet, Carbohydrate-RestrictedDiet, Fat-RestrictedDiet, High-FatFastingFemaleHumansHyperglycemiaInflammationLeukocytes, MononuclearMaleBlood GlucoseDietary Carbohydratescytokinesexerciseglucoseketogenic diet

Identifiers

PMID30303707
PMCPMC6734060
OpenAlexW2896282781

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.