Trial reportEuropean journal of heart failure2018
Phrenic nerve stimulation to treat patients with central sleep apnoea and heart failure.
Trial report in European journal of heart failure, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Pacing therapies for sleep apnea and cardiovascular outcomes: A systematic review.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2021Pooled it
- Highlights in heart failure.ESC heart failure · 2019Pooled it
- Win ratio analysis of transvenous phrenic nerve stimulation to treat central sleep apnoea in heart failure.ESC heart failure · 2025Trial
- Improving Nocturnal Hypoxemic Burden with Transvenous Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea.Journal of cardiovascular translational research · 2021Trial
- How to implant a phrenic nerve stimulator for treatment of central sleep apnea?Journal of cardiovascular electrophysiology · 2019Trial
- Non-positive Airway Pressure Therapies for Obstructive Sleep Apnoea and Central Sleep Apnoea.Cardiac failure review · 2026Review
- Bridge over troubled water: A novel application of an occlusion balloon in phrenic nerve stimulator implantation.HeartRhythm case reports · 2026Article
- The 2025 American Academy of Sleep Medicine Central Sleep Apnoea Guidelines and the Heart Failure Patient.Cardiac failure review · 2026Review
- When LOFTy Ideals Meet Clinical Trial Reality.Annals of the American Thoracic Society · 2025Article
- Revisiting Transvenous Phrenic Nerve Stimulation in Central Sleep Apnoea and Heart Failure: Emerging Innovations in Clinical Trials Analysis.Cardiac failure review · 2025Review
- Phrenic Nerve Stimulation for Central Sleep Apnoea: When and Why?Cardiac failure review · 2025Review
- Home Sleep Apnoea Testing: Advances, Challenges and Considerations in Heart Failure.Cardiac failure review · 2025Review
- Current state of heart failure treatment: are mesenchymal stem cells and their exosomes a future therapy?Frontiers in cardiovascular medicine · 2025Review
- Impact of Hypopnoea Classifications on the Assessment of Sleep Disordered Breathing in Heart Failure.Cardiac failure review · 2025Review
- Treating central sleep apnoea in heart failure: is positive airway pressure and adaptive servo-ventilation in particular the gold standard?European respiratory review : an official journal of the European Respiratory Society · 2024Article
- Beyond Medical Therapy-An Update on Heart Failure Devices.Journal of cardiovascular development and disease · 2024Review
- Phrenic nerve stimulation for the treatment of central sleep apnea in patients with heart failure.Sleep & breathing = Schlaf & Atmung · 2023Article
- Co-activation of the diaphragm and external intercostal muscles through an adaptive closed-loop respiratory pacing controller.Frontiers in rehabilitation sciences · 2023Article
- Phrenic nerve stimulation for treatment of central sleep apnea.Frontiers in sleep · 2023Review
- Modern Approaches for the Treatment of Heart Failure: Recent Advances and Future Perspectives.Pharmaceutics · 2022Review
Corrections and comments
- Commented on by
Authors and funding
14 authors at 11 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe presence of central sleep apnoea (CSA) is associated with poor prognosis in patients with heart failure (HF). The aim of this analysis was to evaluate if using phrenic nerve stimulation to treat CSA in patients with CSA and HF was associated with changes in HF-specific metrics. METHODS AND
resultsAll patients randomized in the remedē System Pivotal Trial and identified at baseline with HF were included (n = 96). Effectiveness data from treatment and former control groups were pooled based on months since therapy activation. Changes from baseline to 6 and 12 months in sleep metrics, Epworth Sleepiness Scale, patient global assessment health-related quality of life, Minnesota Living with Heart Failure Questionnaire (MLHFQ), and echocardiographic parameters are reported. HF hospitalization, cardiovascular death, and the composite of HF hospitalization or cardiovascular death within 6 months are reported by the original randomized group assignment for safety assessment. Sleep metrics and quality of life improved from baseline to 6 and 12 months. At 12 months, MLHFQ scores changed by -6.8 ± 20.0 (P = 0.005). The 6-month rate of HF hospitalization was 4.7% in treatment patients (standard error = 3.3) and 17.0% in control patients (standard error = 5.5) (P = 0.065). Reported adverse events were as expected for a transvenous implantable system.
conclusionsPhrenic nerve stimulation reduces CSA severity in patients with HF. In parallel, this CSA treatment was associated with benefits on HF quality of life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.