Evidence map›Paper›PMID 30303608›Full record

ArticleJournal of biomedical materials research. Part A2018

Ex vivo induction of regulatory T cells from conventional CD4

Neha M Nataraj, Alex P Dang, Lance C Kam, Jounghyun H Lee

Abstract read
In one paragraph

Article in Journal of biomedical materials research. Part A, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Improving regulatory T cell production through mechanosensing.Journal of biomedical materials research. Part A · 2024
    Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Mechanosurveillance: Tiptoeing T Cells.Frontiers in immunology · 2022
    Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Neha M NatarajDepartment of Biomedical Engineering, Columbia University, New York, New York.
Alex P DangDepartment of Biomedical Engineering, Columbia University, New York, New York.
Lance C KamDepartment of Biomedical Engineering, Columbia University, New York, New York.
Jounghyun H LeeDepartment of Biomedical Engineering, Columbia University, New York, New York.
Columbia University · US

Funding

Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Advanced Rigidity-based Material for Enhanced ImmunotherapyR01AI110593 · NIAID · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KAM, LANCE C · 2015 to 2018
$1.6M
Sample Sparing Chambers for Imaging of T cell Response and FunctionU24AI118669 · NIAID · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KAM, LANCE C · 2015 to 2018
$1.2M
Microfluidic devices for investigation of rare T cell populationsF32AI100496 · NIAID · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI LEE, JOUNGHYUN HELEN · 2013 to 2014
$107k
NIAID NIH HHS F32 AI100496NIAID NIH HHS R01 AI110593NIAID NIH HHS U24 AI118669
6 · The paper itself

Abstract

The immune system maintains a balance between protection and tolerance. Regulatory T cells (Tregs) function as a vital tolerance mechanism in the immune system to suppress effector immune cells. Additionally, Tregs can be utilized as a form of immunotherapy for autoimmune disorders. As T cells have previously been shown to exhibit sensitivity to the rigidity of an activating substrate upon activation via IL-2 secretion, we herein explore the previously unknown effect of substrate rigidity on the induction of Tregs from conventional naïve mouse CD4

Indexed as

AnimalsAntibodies, ImmobilizedBiocompatible MaterialsCD4-Positive T-LymphocytesCells, CulturedDimethylpolysiloxanesElastic ModulusLymphocyte ActivationMechanotransduction, CellularMiceT-Lymphocytes, RegulatoryAntibodies, ImmobilizedbaysilonBiocompatible MaterialsDimethylpolysiloxanesMechanosensingpoly(dimethylsiloxane)regulatory T cellssubstrate rigidityT-cell immunotherapy

Identifiers

PMID30303608
PMCPMC6240380
OpenAlexW2895965288

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.