ReviewThe Journal of comparative neurology2019
The modular organization of the cerebral cortex: Evolutionary significance and possible links to neurodevelopmental conditions.
Review in The Journal of comparative neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Engineering Cortical Networks: An Open Platform for Controlled Human Circuit Formation and Synaptic Analysis In Vitro.Advanced healthcare materials · 2025Article
- Complicated architecture of cortical microcircuit: a comprehensive review.Anatomical science international · 2025Review
- Layer-Specific Changes in the Prefrontal Glia/Neuron Ratio Characterizes Patches of Gene Expression Disorganization in Children with Autism.Journal of autism and developmental disorders · 2023Article
- Structural Modularity Tunes Mesoscale Criticality in Biological Neuronal Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Translational neuronal ensembles: Neuronal microcircuits in psychology, physiology, pharmacology and pathology.Frontiers in systems neuroscience · 2022Review
- The inevitable inequality of cortical columns.Frontiers in systems neuroscience · 2022Article
- Long-term morphological and functional dynamics of human stem cell-derived neuronal networks on high-density micro-electrode arrays.Frontiers in neuroscience · 2022Article
- Cellular 3D-reconstruction and analysis in the human cerebral cortex using automatic serial sections.Communications biology · 2021Article
- Self-organization of modular network architecture by activity-dependent neuronal migration and outgrowth.eLife · 2019Article
- The role of somatic mutational events in the pathogenesis of epilepsy.Current opinion in neurology · 2019Review
- The basic repeating modules of the cerebral cortical circuit.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2019Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The recognition of discernible anatomical regularities that appear to self-organize during development makes apparent the modular organization of the cerebral cortex. The metabolic cost engendered in sustaining interneuronal communications has emphasized the viability of short connections among neighboring neurons. This pattern of connectivity establishes a microcircuit which is repeated in parallel throughout the cerebral cortex. This canonical circuit is contained within the smallest module of information processing of the cerebral cortex; one which Vernon Mountcastle called the minicolumn. Plasticity within the brain is accounted, in part, by the presence of weak linkages that allow minicolumns to process information from a variety of sources and to quickly adapt to environmental exigencies without a need for genetic change. Recent research suggests that interlaminar correlated firing between minicolumns during the decision phase of target selection provides for the emergence of some executive functions. Bottlenecks of information processing within this modular minicolumnar organization may account for a variety of mental disorders observed in neurodevelopmental conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.