ArticleMicrobial genomics2019
Australian porcine clonal complex 10 (CC10) Escherichia coli belong to multiple sublineages of a highly diverse global CC10 phylogeny.
Article in Microbial genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
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- Next generation ESKAPE-E superbugs: identifying transmissible locus of stress tolerance and antibiotic resistance in pandemic bacterial lineages.npj antimicrobials and resistance · 2025Article
- Comparative genomic analysis ofMicrobial genomics · 2025Article
- Phenotypic and Genotypic Characterization ofAntibiotics (Basel, Switzerland) · 2024Article
- Bacterial and Genetic Features of Raw Retail Pork Meat: Integrative Analysis of Antibiotic Susceptibility, Whole-Genome Sequencing, and Metagenomics.Antibiotics (Basel, Switzerland) · 2024Article
- Genomic Profiling of Multidrug-Resistant SwineAntibiotics (Basel, Switzerland) · 2023Article
- Phylogenetic Analysis ofAntibiotics (Basel, Switzerland) · 2023Article
- Emergence and Dissemination of Extraintestinal Pathogenic High-Risk International Clones ofLife (Basel, Switzerland) · 2022Review
- Urban Wildlife Crisis: Australian Silver Gull Is a Bystander Host to Widespread Clinical Antibiotic Resistance.mSystems · 2022Article
- Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China.Nature communications · 2022Article
- A role for ColV plasmids in the evolution of pathogenic Escherichia coli ST58.Nature communications · 2022Article
- Carbapenemase-Producing Extraintestinal PathogenicFrontiers in microbiology · 2022Article
- Genetic and Ecological Diversity ofFrontiers in microbiology · 2022Article
- Genomic epidemiological analysis ofFrontiers in veterinary science · 2022Article
- Alterations in chromosomal genesMicrobial genomics · 2021Article
- First Detection of Human ST131-CTX-M-15-O25-B2 Clone and High-Risk Clonal Lineages of ESBL/pAmpC-ProducingAntibiotics (Basel, Switzerland) · 2021Article
- Antimicrobial Resistance Profiling and Molecular Epidemiological Analysis of Extended Spectrum β-Lactamases Produced by Extraintestinal InvasiveFrontiers in microbiology · 2021Article
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3 authors.
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Abstract
We recently identified clonal complex 10 (CC10) Escherichia coli as the predominant clonal group in two populations of healthy Australian food-production pigs. CC10 are highly successful, colonizing humans, food-production animals, fresh produce and environmental niches. Furthermore, E. coli within CC10 are frequently drug resistant and increasingly reported as human and animal extra-intestinal pathogens. In order to develop a high-resolution global phylogeny and determine the repertoire of antimicrobial-resistance genes, virulence-associated genes and plasmid types within this clonal group, we downloaded 228 publicly available CC10 short-read genome sequences for comparison with 20 porcine CC10 we have previously described. Core genome single nucleotide polymorphism phylogeny revealed a highly diverse global phylogeny consisting of multiple lineages that did not cluster by geography or source of the isolates. Australian porcine strains belonged to several of these divergent lineages, indicative that CC10 is present in these animals due to multiple colonization events. Differences in resistance gene and plasmid carriage between porcine strains and the global collection highlighted the role of lateral gene transfer in the evolution of CC10 strains. Virulence profiles typical of extra-intestinal pathogenic E. coli were present in both Australian porcine strains and the broader collection. As both the core phylogeny and accessory gene characteristics appeared unrelated to the geography or source of the isolates, it is likely that the global expansion of CC10 is not a recent event and may be associated with faecal carriage in humans.
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