ArticleEnvironmental science & technology2018
A High-Resolution Spatial Model to Predict Exposure to Pharmaceuticals in European Surface Waters: ePiE.
Article in Environmental science & technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 73 citations in OpenAlex.
- Spatially and Seasonally Resolved Predictions Reveal Widespread Ecotoxicological Risk from Pharmaceutical Mixtures in German (Saxon) Rivers.Environmental science & technology · 2025Article
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- Continuous improvement towards environmental protection for pharmaceuticals: advancing a strategy for Europe.Environmental sciences Europe · 2025Review
- Assessing the impact of organic and inorganic micropollutants released from a wastewater treatment plant on humans and aquatic environment, Al-Hoceima city, Morocco.Toxicology reports · 2024Article
- Review
- Sensory-Motor Perturbations in Larval Zebrafish (International journal of molecular sciences · 2022Article
- FutureStreams, a global dataset of future streamflow and water temperature.Scientific data · 2022Article
- Ecological Risk Assessment of Pharmaceuticals in the Transboundary Vecht River (Germany and The Netherlands).Environmental toxicology and chemistry · 2022Article
- Pharmaceutical pollution: Prediction of environmental concentrations from national wholesales data.Open research Europe · 2022Article
- Screening-Level Estimates of Environmental Release Rates, Predicted Exposures, and Toxic Pressures of Currently Used Chemicals.Environmental toxicology and chemistry · 2020Article
- Implications of Trophic Variability for Modeling Biomagnification of POPs in Marine Food Webs in the Svalbard Archipelago.Environmental science & technology · 2020Article
- Environmental Risk Assessment for the Active Pharmaceutical Ingredient Mycophenolic Acid in European Surface Waters.Environmental toxicology and chemistry · 2019Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental risk assessment of pharmaceuticals requires the determination of their environmental exposure concentrations. Existing exposure modeling approaches are often computationally demanding, require extensive data collection and processing efforts, have a limited spatial resolution, and have undergone limited evaluation against monitoring data. Here, we present ePiE (exposure to Pharmaceuticals in the Environment), a spatially explicit model calculating concentrations of active pharmaceutical ingredients (APIs) in surface waters across Europe at ∼1 km resolution. ePiE strikes a balance between generating data on exposure at high spatial resolution while having limited computational and data requirements. Comparison of model predictions with measured concentrations of a diverse set of 35 APIs in the river Ouse (UK) and Rhine basins (North West Europe), showed around 95% were within an order of magnitude. Improved predictions were obtained for the river Ouse basin (95% within a factor of 6; 55% within a factor of 2), where reliable consumption data were available and the monitoring study design was coherent with the model outputs. Application of ePiE in a prioritisation exercise for the Ouse basin identified metformin, gabapentin, and acetaminophen as priority when based on predicted exposure concentrations. After incorporation of toxic potency, this changed to desvenlafaxine, loratadine, and hydrocodone.
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