Evidence map›Paper›PMID 30303062›Full record

ArticleCardiology in the young2018

Paediatric pulmonary hypertension caused by an ACVRL1 mutation presenting as Ortner syndrome.

Batool Alsheikh, Othman Aljohani, Nicole G Coufal

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiology in the young, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Batool Alsheikh1Division of Pediatric Critical Care,Rady Children's Hospital UCSD,San Diego,CAUSA.
Othman Aljohani2Division of Pediatric Cardiology,Rady Children's Hospital UCSD,San Diego,CA,USA.
Nicole G Coufal1Division of Pediatric Critical Care,Rady Children's Hospital UCSD,San Diego,CAUSA.
Rady Children's Hospital-San Diego · US

Funding

ConProject-001U19HD077693 · NICHD · RADY PEDIATRIC GENOMICS & SYSTEMS MEDICINE INSTITUTE · PI KINGSMORE, STEPHEN FRANCIS · 2013 to 2018
$6.2M
NICHD NIH HHS U19 HD077693
6 · The paper itself

Abstract

We report a rare aetiology of vocal cord paralysis secondary to undiagnosed severe pulmonary hypertension from a de novo ACVRL1 variant identified by whole-genome sequencing. The patient had a partial response to intravenous treprostinil in addition to inhaled nitric oxide, bosentan, and sildenafil.

Indexed as

Activin Receptors, Type IIAntihypertensive AgentsEpoprostenolHumansHypertension, PulmonaryInfantMaleMutationVocal Cord ParalysisActivin Receptors, Type IIACVRL1 protein, humanAntihypertensive AgentsEpoprostenoltreprostinilhereditary haemorrhagic telangiectasia type 2Ortner syndromePulmonary arterial hypertensionveno-arterial extracorporeal membrane oxygenation

Identifiers

PMID30303062
PMCPMC6237639
OpenAlexW2895956510

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.