Evidence map›Paper›PMID 30303018›Full record

ArticleJournal of neurogenetics2018

Pleiotropy of the Drosophila melanogaster foraging gene on larval feeding-related traits.

A M Allen, I Anreiter, A Vesterberg, S J Douglas, M B Sokolowski

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurogenetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Characterizing the Protein Isoforms ofInternational journal of molecular sciences · 2023
    Article
  4. Expression of theJournal of neurogenetics · 2021
    Article
  5. TheJournal of neurogenetics · 2021
    Article
  6. Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

A M Allena Department of Cell and Systems Biology , University of Toronto , Toronto , Canada.
I Anreiterb Department of Ecology and Evolutionary Biology , University of Toronto , Toronto , Canada.ORCID 0000-0002-9563-0579
A Vesterbergb Department of Ecology and Evolutionary Biology , University of Toronto , Toronto , Canada.
S J Douglasa Department of Cell and Systems Biology , University of Toronto , Toronto , Canada.
M B Sokolowskia Department of Cell and Systems Biology , University of Toronto , Toronto , Canada.ORCID 0000-0002-7462-8007
University of Toronto · CACanadian Institute for Advanced Research · CA

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Genes underlying food-related behaviors in Drosphila.R01DK070141 · NIDDK · UNIVERSITY OF TORONTO · PI SOKOLOWSKI, MARLA B · 2004 to 2007
$954k
CIHRNIDDK NIH HHS R01 DK070141NIH HHS P40 OD018537
6 · The paper itself

Abstract

Little is known about the molecular underpinning of behavioral pleiotropy. The Drosophila melanogaster foraging gene is highly pleiotropic, affecting many independent larval and adult phenotypes. Included in foraging's multiple phenotypes are larval foraging path length, triglyceride levels, and food intake. foraging has a complex structure with four promoters and 21 transcripts that encode nine protein isoforms of a cGMP dependent protein kinase (PKG). We examined if foraging's complex molecular structure underlies the behavioral pleiotropy associated with this gene. Using a promotor analysis strategy, we cloned DNA fragments upstream of each of foraging's transcription start sites and generated four separate for

Indexed as

AnimalsCyclic GMP-Dependent Protein KinasesDrosophila melanogasterDrosophila ProteinsFeeding BehaviorGenetic PleiotropyLarvaPhenotypePromoter Regions, GeneticCyclic GMP-Dependent Protein KinasesDrosophila Proteinsfor protein, DrosophilaDrosophila melanogasterforaging genelarval phenotypesmultiple promoter analysispleiotropy

Identifiers

PMID30303018
PMCPMC6309726
OpenAlexW2896199377

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.