ArticleAging cell2018
Dysregulated homeostatic pathways in sarcopenia among frail older adults.
Article in Aging cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Trial
- Sarcopenia is associated with poor survival among patients with non-metastatic renal cell carcinoma and venous tumor thrombus.World journal of urology · 2026Article
- TyG Index and Frailty as Composite Biomarkers of Cardiometabolic Risk and Mortality Across CKM Stages 0-3.Metabolites · 2026Article
- Association of Leptin in Sarcopenia and Bone Density in Elderly Women: An Observational Analysis.Diagnostics (Basel, Switzerland) · 2025Article
- The Prevalence of Malnutrition and Sarcopenia and the Relationship with Inflammation and Anemia Among Community-Dwelling Older Adults: A Preliminary Cross-Sectional Study.Geriatrics (Basel, Switzerland) · 2024Article
- Impact of frailty on postoperative outcomes after hepatectomy: A systematic review and meta-analysis.World journal of gastrointestinal surgery · 2024Article
- Impact of frailty on short-term postoperative outcomes in patients undergoing colorectal cancer surgery: A systematic review and meta-analysis.World journal of gastrointestinal surgery · 2024Article
- Aging induces region-specific dysregulation of hormone synthesis in the primate adrenal gland.Nature aging · 2024Article
- Bibliometric and scientometric analysis on biomarkers and molecular mechanisms for physical frailty and sarcopenia.Frontiers in medicine · 2024Article
- Multisystem physiological perspective of human frailty and its modulation by physical activity.Physiological reviews · 2023Review
- Recent Advances in the Knowledge of the Mechanisms of Leptin Physiology and Actions in Neurological and Metabolic Pathologies.International journal of molecular sciences · 2023Review
- Paradigm shift in gastrointestinal surgery - combating sarcopenia with prehabilitation: Multimodal review of clinical and scientific data.World journal of gastrointestinal surgery · 2021Review
- The association between sarcopenia susceptibility and polymorphisms of FTO, ACVR2B, and IRS1 in Tibetans.Molecular genetics & genomic medicine · 2021Article
- Cachexia as Evidence of the Mechanisms of Resistance and Tolerance during the Evolution of Cancer Disease.International journal of molecular sciences · 2021Review
- Role of miRNAs and lncRNAs in dexamethasone-induced myotube atrophyExperimental and therapeutic medicine · 2021Article
- Acute Effects of Low- and High-Speed Resistance Exercise on Cognitive Function in Frail Older Nursing-Home Residents: A Randomized Crossover Study.Journal of aging research · 2021Article
- Shifting Tides Toward a Proactive Patient-Centered Approach in Dysphagia Management of Neurodegenerative Disease.American journal of speech-language pathology · 2020Article
- Whey for Sarcopenia; Can Whey Peptides, Hydrolysates or Proteins Play a Beneficial Role?Foods (Basel, Switzerland) · 2020Review
- Inter-correlations Among Clinical, Metabolic, and Biochemical Parameters and Their Predictive Value in Healthy and Overtrained Male Athletes: The EROS-CORRELATIONS Study.Frontiers in endocrinology · 2019Article
- Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Sarcopenia, a core feature of the physical frailty syndrome, is characterized by multisystem physiological dysregulation. No study has explored qualitatively the hierarchical network of relationships among different dysregulated pathways involved in the pathogenesis of sarcopenia. We used 40 blood biomarkers belonging to community-dwelling prefrail and frail older persons to derive measures of multiple physiological pathways, and structural equation modeling to generate path network models of the multisystem physiological dysregulations associated with muscle mass and function (MMF). Insulin-leptin signaling and energy regulation, anabolic sex steroid regulation (testosterone, leptin), and tissue oxygenation (hemoglobin, red cell count) appear to be primary mediating factors exerting direct influences on MMF. There was additionally secondary mediatory involvement of myocyte- and adipocyte-derived cytokines, hypothalamic pituitary adrenal (HPA) stress hormones (cortisol, DHEAS), glomerular function, and immune cell regulatory and inflammatory cytokines and glycoproteins. We conclude that within a hierarchical network of multisystem physiological dysregulations in sarcopenia, dysregulated anabolic and catabolic pathways via sex steroids and insulin-leptin dual signaling and tissue hypoxemia are primary physiological dysregulations responsible for sarcopenia and frailty.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.