ArticleParasitology research2018
Cercarial dermatitis: a systematic follow-up study of human cases with implications for diagnostics.
Article in Parasitology research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Human cercarial dermatitis (HCD) in the UK: an overlooked and under-reported nuisance?Parasites & vectors · 2024Pooled it
- Emerging zoonotic risk: molecular detection ofScience in One Health · 2026Article
- The avian schistosomeFood and waterborne parasitology · 2025Article
- TRPV1+ neurons promote cutaneous immunity against Schistosoma mansoni.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Molecular detection and identification of Trichobilharzia: development of a LAMP, qPCR, and multiplex PCR toolkit.Parasites & vectors · 2025Article
- From cercariae to chronic inflammation: understanding schistosome infection and host immune responses.Frontiers in immunology · 2025Review
- The first record the Limnia unguicornis (Diptera, Sciomyzidae) parasites on a vulnerable pulmonate land snail, Vertigo moulinsiana (Gastropoda: Eupulmonata: Vertiginidae) and a literature review on Limnia species.Parasitology research · 2024Review
- MrgprA3 neurons drive cutaneous immunity against helminths through selective control of myeloid-derived IL-33.Nature immunology · 2024Article
- Zoonotic Threats: The (Re)emergence of Cercarial Dermatitis, Its Dynamics, and Impact in Europe.Pathogens (Basel, Switzerland) · 2024Review
- Expanding the swimmer's itch pool of the Benelux: a first record of the neurotropic Trichobilharzia regenti and potential link to human infection.Parasites & vectors · 2024Article
- Other Schistosomatoidea and Diplostomoidea.Advances in experimental medicine and biology · 2024Review
- Molecular identification ofPeerJ · 2024Article
- Article
- The Tails of Two Avian Schistosomes: Paired Exposure Study DemonstratesPathogens (Basel, Switzerland) · 2022Article
- Mechanisms of the host immune response and helminth-induced pathology during Trichobilharzia regenti (Schistosomatidae) neuroinvasion in mice.PLoS pathogens · 2022Article
- First Record ofPathogens (Basel, Switzerland) · 2021Article
- Nitric oxide debilitates the neuropathogenic schistosome Trichobilharzia regenti in mice, partly by inhibiting its vital peptidases.Parasites & vectors · 2020Article
- Confirmation of the presence of zoonotic Trichobilharzia franki following a human cercarial dermatitis outbreak in recreational water in Slovakia.Parasitology research · 2020Article
- Schistosoma species detection by environmental DNA assays in African freshwaters.PLoS neglected tropical diseases · 2020Article
- Isoforms of Cathepsin B1 in Neurotropic Schistosomula ofFrontiers in cellular and infection microbiology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Cercarial dermatitis (CD) is an allergic skin disease that rises in consequence of infection by invasive stages (cercariae) of trematodes of the family Schistosomatidae. CD has been considered a re-emerging disease, human cases have been reported from all continents, and tourism-threatening outbreaks occur even in frequented recreational areas. Although the symptoms of CD are generally known, the data on immune response in human patients are sporadic and incomprehensive. In the present study, we attempted to correlate the symptoms, personal history, and time course of CD in human patients with differential cell counts, dynamics of selected cytokines, and dynamics and quality of antibody response. By a systematic follow-up, we obtained a uniquely complex dataset from ten persons accidentally and concurrently infected by the same parasite species in the same locality. The onset of CD was significantly faster, and the symptoms were heavier in participants with a history of CD if compared to naive ones, who, however, also developed some of the symptoms. The repeatedly infected persons had elevated proportion of eosinophils 1 week post exposure (p.e.) and a stronger specific IgG but not IgM response, whereas specific IgE response was not observed. Increased serum levels of IL-4 occurred 1 and 3 week(s) p.e. in all participants. There was high variability in individual immunoblot patterns of IgG response, and no antigen with a universal diagnostic potential was confirmed. The presented analyses suggested that a complex approach can improve the accuracy of the diagnosis of CD, but component data should be interpreted carefully.
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