Evidence map›Paper›PMID 30302516›Full record

ReviewDer Nervenarzt2018

[Patho- and therapyepigenetics of mental disorders].

Christiane Ziegler, Miriam A Schiele, Katharina Domschke

Abstract readReview
PubMed Publisher
In one paragraph

Review in Der Nervenarzt, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Anxiolytic Effect of Carvedilol in Chronic Unpredictable Stress Model.Oxidative medicine and cellular longevity · 2022
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christiane ZieglerKlinik für Psychiatrie und Psychotherapie, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Hauptstraße 5, 79104, Freiburg, Deutschland.
Miriam A SchieleKlinik für Psychiatrie und Psychotherapie, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Hauptstraße 5, 79104, Freiburg, Deutschland.
Katharina DomschkeKlinik für Psychiatrie und Psychotherapie, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Hauptstraße 5, 79104, Freiburg, Deutschland. katharina.domschke@uniklinik-freiburg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic mechanisms, such as DNA methylation and histone modifications are biochemical alterations of the DNA or its spatial structure. They regulate gene function, can be modified by environmental influences and are temporally dynamic. In this review, the current state of knowledge regarding the role of epigenetics in the pathogenesis of mental disorders is summarized exemplarily for schizophrenia, depression, anxiety disorders and posttraumatic stress disorder. Additionally, findings on epigenetic alterations in the course of pharmacotherapeutic and psychotherapeutic interventions are presented. Epigenetic mechanisms have a central function at the crossroads between genes and environment and consequently in the vulnerability-stress model of mental disorders. Prospectively, in line with a precision medicine approach epigenetic profiles may represent useful markers of disease risk and therapy response or even constitute new druggable targets.

Indexed as

Epigenesis, GeneticMental DisordersDNA MethylationHumansSchizophreniaStress Disorders, Post-TraumaticDNA methylationEpigenetic markersGene-environment interactionHistone modificationsResilience

Identifiers

PMID30302516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.