ArticleNeuroradiology2018
Assessment of myelination progression in subcortical white matter of children aged 6-48 months using T2-weighted imaging.
Article in Neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Abnormal thalamocortical connectivity of preterm infants with elevated thyroid stimulating hormone identified with diffusion tensor imaging.Scientific reports · 2022Article
- A Multicenter Preclinical MRI Study: Definition of Rat Brain Relaxometry Reference Maps.Frontiers in neuroinformatics · 2020Article
- Transient Hypothyroidism During Lactation Alters the Development of the Corpus Callosum in Rats. AnFrontiers in neuroanatomy · 2020Article
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9 authors.
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Abstract
purposeThis study aims to provide a screening scoring method by assessing the age-related change of subcortical white matter (WM) myelination via T2-weighted imaging (T2WI).
methodsThis study retrospectively recruited 109 children aged 6-48 months without abnormalities on MRI. Based on Parazzini's study, we developed a modified T2WI-based method to assess subcortical WM myelination (frontal, temporal, parietal, occipital lobes, and insula) by scoring WM's signal changes. Inter- and intra-observer agreements were evaluated by Bland-Altman plot. Age-related changes of myelination score were explored by locally weighted scatterplot smoothing (LOESS), linear regression, and Spearman correlation coefficients (r). Relationships between diffusion tensor imaging (DTI) metrics and total myelination score were investigated to further validate practicability of the scoring method by tract-based spatial statistics (TBSS).
resultsThis method showed good intra-observer (mean difference = 0.18, SD = 0.95) and inter-observer agreements (mean difference = - 0.06, SD = 1.01). The LOESS and linear regression results indicated that myelination proceeded in two phases: a period of rapid growth (6-20 months; slope = 0.561) and one of slower growth (21-48 months; slope = 0.097). Significant correlations between myelination score and age were observed in whole subcortical WM (r = 0.945; P < 0.001) and all regional subcortical WM (r
conclusionThe modified T2WI-based screening scoring method is easily feasible to assess myelination progression of subcortical WM, especially suitable for children aged 6-20 months. It may show potential in identifying individual developmental abnormalities by scoring assessment in the future clinical practice.
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